Sökning: onr:"swepub:oai:DiVA.org:ltu-103207" >
C1QA and COMP: plas...
C1QA and COMP: plasma-based biomarkers for early diagnosis of pancreatic neuroendocrine tumors
-
- Gorai, Priya Kumari (författare)
- Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
-
- Bharti, Prahalad Singh (författare)
- Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
-
- Kumar, Shashi (författare)
- Department of Metabolic Engineering, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
-
visa fler...
-
- Rajacharya, Girish H. (författare)
- Department of Metabolic Engineering, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
-
- Bandyopadhyay, Sabyasachi (författare)
- Centralized Core Research Facility, All India Institute of Medical Sciences, New Delhi, India
-
- Pal, Sujoy (författare)
- Department of GI Surgery, All India Institute of Medical Sciences, New Delhi, India
-
- Dhingra, Renu (författare)
- Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
-
- Kumar, Rakesh (författare)
- Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
-
- Nikolajeff, Fredrik (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik
-
- Kumar, Saroj (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
-
- Rani, Neerja (författare)
- Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
-
visa färre...
-
(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
-
Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://ltu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Pancreatic Neuroendocrine tumors (PanNET) are challenging to diagnose and often detected at advanced stages due to a lack of specific and sensitive biomarkers. This study utilized proteomics as a valuable approach for cancer biomarker discovery; therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects (3 controls; 5 Grade I, 4 Grade II PanNET patients) to identify potential proteins capable of effectively distinguishing PanNET from healthy controls. Data are available via ProteomeXchange with the identifier PXD045045. 13.2% of proteins were uniquely identified in PanNET, while 60% were commonly expressed in PanNET and controls. 17 proteins exhibiting significant differential expression between PanNET and controls were identified with downstream analysis. Further, 5 proteins (C1QA, COMP, HSP90B1, ITGA2B, and FN1) were selected by pathway analysis and were validated using Western blot analysis. Significant downregulation of C1QA (p = 0.001: within groups, 0.03: control vs. grade I, 0.0013: grade I vs. grade II) and COMP (p = 0.011: within groups, 0.019: control vs grade I) were observed in PanNET Grade I & II than in controls. Subsequently, ELISA on 38 samples revealed significant downregulation of C1QA and COMP with increasing disease severity. This study shows the potential of C1QA and COMP in the early detection of PanNET, highlighting their role in the search for early-stage (Grade-I and Grade-II) diagnostic markers and therapeutic targets for PanNET.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Biomedical Engineering
- Medicinsk teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gorai, Priya Kum ...
-
Bharti, Prahalad ...
-
Kumar, Shashi
-
Rajacharya, Giri ...
-
Bandyopadhyay, S ...
-
Pal, Sujoy
-
visa fler...
-
Dhingra, Renu
-
Kumar, Rakesh
-
Nikolajeff, Fred ...
-
Kumar, Saroj
-
Rani, Neerja
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Scientific Repor ...
- Av lärosätet
-
Luleå tekniska universitet