Sökning: onr:"swepub:oai:DiVA.org:ltu-14595" >
Solid state charact...
Solid state characterization of sodium eritadenate
-
- Enman, Josefine (författare)
- Luleå tekniska universitet,Industriell miljö- och processteknik
-
- Patra, Anuttam (författare)
- Luleå tekniska universitet,Industriell miljö- och processteknik
-
- Ramser, Kerstin (författare)
- Luleå tekniska universitet,Signaler och system
-
visa fler...
-
- Rova, Ulrika (författare)
- Luleå tekniska universitet,Industriell miljö- och processteknik
-
- Berglund, Kris (författare)
- Luleå tekniska universitet,Industriell miljö- och processteknik
-
visa färre...
-
(creator_code:org_t)
- Scientific Research Publishing, Inc. 2011
- 2011
- Engelska.
-
Ingår i: American Journal of Analytical Chemistry. - : Scientific Research Publishing, Inc.. - 2156-8251 .- 2156-8278. ; 2:2, s. 164-173
- Relaterad länk:
-
https://ltu.diva-por... (primary) (Raw object)
-
visa fler...
-
http://www.scirp.org...
-
https://urn.kb.se/re...
-
https://doi.org/10.4...
-
visa färre...
Abstract
Ämnesord
Stäng
- Knowledge of the solid state is of great importance in the development of a new active pharmaceutical ingredient, since the solid form often dictates the properties and performance of the drug. In the present study, solid state characteristics of the sodium salt of the candidate cholesterol reducing compound eritadenine, 2(R), 3(R))-dihydroxy-4-(9-adenyl)-butanoic acid, were investigated. The compound was crystallized by slow cooling from water and various aqueous ethanol solutions, at different temperatures. Further, the compound solution was subjected to lyophilization and to high vacuum drying. The resulting solids were screened for polymorphism by micro Raman spectroscopy (λex = 830 nm) and the crystallinity was investigated by X-ray powder diffraction. Further, thermal analysis was applied to study possible occurrence of solvates or hydrates. Solids obtained from slow cooling showed crystallinity, whereas rapid cooling gave rise to more amorphous solids. Analysis of difference spectra of the Raman data for solids obtained from slow cooling of solution revealed subtle differences in the structures between crystals derived from pure water and crystals derived from aqueous ethanol solutions. Finally, from the thermal analysis it was deduced that crystals obtained from pure water were stoichiometrically dihydrates whereas crystals obtained from aqueous ethanol solutions were 2.5 hydrates; this formation of different hydrates were supported by the Raman difference analysis.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioprocessteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioprocess Technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
Nyckelord
- Biokemisk processteknik
- Biochemical Process Engineering
- Medical Engineering for Healthcare
- Medicinsk teknik för hälsovård
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas