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Effect of plasticiz...
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
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- Rao Vuddanda, Parameswara (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Montenegro-Nicolini, Miguel (författare)
- Department of Pharmaceutical Sciences and Technology, University of Chile, Santiago
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- Morales, Javier O. (författare)
- Department of Pharmaceutical Sciences and Technology, University of Chile, Santiago
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visa fler...
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- Velaga, Sitaram (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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visa färre...
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- Engelska.
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Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 96, s. 290-298
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The effect of different plasticizers (glycerol, vitamin E TPGS and triacetin) and their concentrations on the physico-mechanical properties of pullulan based oral films was studied. A full factorial (32) design of experiments was used. Elastic modulus, tensile strength, elongation at break and disintegration time were selected as response variables. Modulated differential scanning calorimeter (MDSC) was used for determining glass transition temperature (Tg) of pullulan films. The surface morphology of films was evaluated by SEM, while ATR-FTIR was used to obtain a molecular level understanding of polymer-plasticizer interactions. The DoE analysis allowed for the modelling of tensile strength and elongation at break. The highest elongations were observed in glycerol at 20% w/w. Majority of the films disintegrated within one minute without significant differences. ATR-FTIR spectra of pullulan alone and different plasticizer blend films show characteristic molecular interactions. The present study concluded that glycerol is suitable plasticizer compared to others for manufacturing pullulan based oral films.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- Health Science
- Hälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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