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Cardiac biomarkers ...
Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease
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- Nilsson, Ulf (författare)
- Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University Hospital, B41, 90185, Umeå, Sweden
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- Mills, Nicholas L. (författare)
- BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
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- McAllister, David A. (författare)
- Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
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- Backman, Helena (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, The OLIN unit, Section of Sustainable Health, Umeå University, Umeå, Sweden
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- Stridsman, Caroline (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Department of Health Science, Division of Nursing, Luleå University of Technology, Luleå, Sweden.
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, The OLIN unit, Section of Sustainable Health, Umeå University, Umeå, Sweden
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, The OLIN unit, Section of Sustainable Health, Umeå University, Umeå, Sweden
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- Fujisawa, Takeshi (författare)
- BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
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- Blomberg, Anders, 1961- (författare)
- Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University Hospital, B41, 90185, Umeå, Sweden
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- Lindberg, Anne (författare)
- Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University Hospital, B41, 90185, Umeå, Sweden
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(creator_code:org_t)
- 2020-06-26
- 2020
- Engelska.
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Ingår i: Respiratory Research. - : Springer Nature. - 1465-9921 .- 1465-993X. ; 21
- Relaterad länk:
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https://doi.org/10.1...
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https://respiratory-...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundIschemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individuals with COPD and normal lung function, respectively.MethodsIn 2002–04, all individuals with airway obstruction (FEV1/VC < 0.70, n = 993) were identified from population-based cohorts, together with age and sex-matched non-obstructive referents. At re-examination in 2005, spirometry, Minnesota-coded ECG and analyses of high-sensitivity cardiac troponin I (hs-cTnI) were performed in individuals with COPD (n = 601) and those with normal lung function (n = 755). Deaths were recorded until December 31st, 2010.ResultsHs-cTnI concentrations were above the risk stratification threshold of ≥5 ng/L in 31.1 and 24.9% of those with COPD and normal lung function, respectively. Ischemic ECG abnormalities were present in 14.8 and 13.4%, while 7.7 and 6.6% had both elevated hs-cTnI concentrations and ischemic ECG abnormalities. The 5-year cumulative mortality was higher in those with COPD than those with normal lung function (13.6% vs. 7.7%, p < 0.001). Among individuals with COPD, elevated hs-cTnI both independently and in combination with ischemic ECG abnormalities were associated with an increased risk for death (adjusted hazard ratio [HR]; 95% confidence interval [CI] 2.72; 1.46–5.07 and 4.54; 2.25–9.13, respectively). Similar associations were observed also among individuals with COPD without reported ischemic heart disease.ConclusionsIn this study, elevated hs-cTnI concentrations in combination with myocardial ischemia on the electrocardiogram were associated with a more than four-fold increased risk for death in a population-based COPD-cohort, independent of disease severity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- COPD
- Multimorbidity
- Myocardial ischemia
- Troponin
- Electrocardiography
- Mortality
- Nursing
- Omvårdnad
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nilsson, Ulf
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Mills, Nicholas ...
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McAllister, Davi ...
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Backman, Helena
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Stridsman, Carol ...
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Hedman, Linnea, ...
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Rönmark, Eva
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Fujisawa, Takesh ...
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Blomberg, Anders ...
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Lindberg, Anne
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Omvårdnad
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Respiratory Rese ...
- Av lärosätet
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Luleå tekniska universitet
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Umeå universitet