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Cardiac biomarkers ...
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Nilsson, UlfUmeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University Hospital, B41, 90185, Umeå, Sweden
(författare)
Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-06-26
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Springer Nature,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:ltu-80128
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https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-80128URI
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https://doi.org/10.1186/s12931-020-01430-zDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173641URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Validerad;2020;Nivå 2;2020-07-01 (alebob)
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BackgroundIschemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individuals with COPD and normal lung function, respectively.MethodsIn 2002–04, all individuals with airway obstruction (FEV1/VC < 0.70, n = 993) were identified from population-based cohorts, together with age and sex-matched non-obstructive referents. At re-examination in 2005, spirometry, Minnesota-coded ECG and analyses of high-sensitivity cardiac troponin I (hs-cTnI) were performed in individuals with COPD (n = 601) and those with normal lung function (n = 755). Deaths were recorded until December 31st, 2010.ResultsHs-cTnI concentrations were above the risk stratification threshold of ≥5 ng/L in 31.1 and 24.9% of those with COPD and normal lung function, respectively. Ischemic ECG abnormalities were present in 14.8 and 13.4%, while 7.7 and 6.6% had both elevated hs-cTnI concentrations and ischemic ECG abnormalities. The 5-year cumulative mortality was higher in those with COPD than those with normal lung function (13.6% vs. 7.7%, p < 0.001). Among individuals with COPD, elevated hs-cTnI both independently and in combination with ischemic ECG abnormalities were associated with an increased risk for death (adjusted hazard ratio [HR]; 95% confidence interval [CI] 2.72; 1.46–5.07 and 4.54; 2.25–9.13, respectively). Similar associations were observed also among individuals with COPD without reported ischemic heart disease.ConclusionsIn this study, elevated hs-cTnI concentrations in combination with myocardial ischemia on the electrocardiogram were associated with a more than four-fold increased risk for death in a population-based COPD-cohort, independent of disease severity.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mills, Nicholas L.BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
(författare)
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McAllister, David A.Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
(författare)
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Backman, HelenaUmeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, The OLIN unit, Section of Sustainable Health, Umeå University, Umeå, Sweden(Swepub:umu)heaban01
(författare)
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Stridsman, CarolineLuleå tekniska universitet,Omvårdnad och medicinsk teknik,Department of Health Science, Division of Nursing, Luleå University of Technology, Luleå, Sweden.(Swepub:ltu)carstr
(författare)
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Hedman, Linnea,1979-Umeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, The OLIN unit, Section of Sustainable Health, Umeå University, Umeå, Sweden(Swepub:umu)evli0029
(författare)
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Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, The OLIN unit, Section of Sustainable Health, Umeå University, Umeå, Sweden(Swepub:umu)evra0004
(författare)
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Fujisawa, TakeshiBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
(författare)
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Blomberg, Anders,1961-Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University Hospital, B41, 90185, Umeå, Sweden(Swepub:umu)anbl0001
(författare)
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Lindberg, AnneUmeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University Hospital, B41, 90185, Umeå, Sweden(Swepub:umu)anelig02
(författare)
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Umeå universitetAvdelningen för medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Respiratory Research: Springer Nature211465-99211465-993X
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Nilsson, Ulf
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Mills, Nicholas ...
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McAllister, Davi ...
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Backman, Helena
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Stridsman, Carol ...
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Hedman, Linnea, ...
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Rönmark, Eva
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Fujisawa, Takesh ...
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Blomberg, Anders ...
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Lindberg, Anne
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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MEDICIN OCH HÄLS ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Luleå tekniska universitet
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Umeå universitet