Solubility of carbamazepine, nicotinamide and carbamazepine-nicotinamide cocrystal in ethanol-water mixtures

• Solubility is an important physiochemical property of pharmaceutical compounds, and cocrystallization is one method used to improve the solubility of drugs. Carbamazepine is a drug from class II, according to the biopharmaceutical classification system, and it forms a cocrystal with nicotinamide. Carbamazepine cocrystallized with nicotinamide was synthesized using the solvent evaporation approach, and its characteristics were determined using differential scanning calorimetry and powder X-ray diffractometry. The solubility of various solid phases in ethanol. +. water mixtures was investigated at different temperatures using the shake-flask method, and the resulting precipitates were characterized. The solubility of carbamazepine was increased with the addition of ethanol up to a mass fraction of 0.8. Nevertheless, maximum solubility of NIC is observed in neat solvent (water). While the solubility of a cocrystal depends on the concentration of the coformer and its stability in the solution.

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MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Other Health Sciences (hsv//eng)

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Health Science

Hälsovetenskap

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