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Arginine and Caries...
Arginine and Caries Prevention : A Systematic Review
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- Astvaldsdottir, Alfheiour (författare)
- Karolinska Institutet
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- Naimi-Akbar, Aron (författare)
- Department of Dental Medicine, Karolinska Institutet, PO Box 4064, Huddinge, SE-14104, Sweden; Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Huddinge, Sweden
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- Davidson, Thomas (författare)
- Linköpings universitet,Avdelningen för hälso- och sjukvårdsanalys,Medicinska fakulteten
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- Brolund, Agneta (författare)
- Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden
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- Lintamo, Laura (författare)
- Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden
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- Granath, Anna Attergren (författare)
- Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden
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- Tranæus, Sofia (författare)
- Karolinska Institutet,Malmö högskola,Odontologiska fakulteten (OD),Department of Dental Medicine, Karolinska Institutet, PO Box 4064, Huddinge, SE-14104, Sweden; Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden,Karolinska Institute, Sweden; Swedish Agency Health Technology Assessment and Assessment, Sweden; Malmt University, Sweden
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- Östlund, Pernilla (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden,Swedish Agency Health Technology Assessment and Assessment, Sweden; Malmt University, Sweden
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(creator_code:org_t)
- 2016-07-12
- 2016
- Engelska.
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Ingår i: Caries Research. - : S. Karger. - 0008-6568 .- 1421-976X. ; 50:4, s. 383-393
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: To evaluate the available evidence that the use of arginine-containing dental care products prevents the development of new caries lesions and the progression of existing lesions. Search Methods: We performed a systematic literature search of databases including PubMed, the Cochrane Library and EMBASE. Selection Criteria: We selected randomized controlled trials of treatment with arginine in fluoride-containing dental products measuring dental caries incidence or progression in children, adults and elderly subjects. Data Collection and Analysis: Two review authors independently assessed trials for risk of bias and evaluated overall study quality using the GRADE classification. Main Results: Due to conflicts of interest and weak transferability to Swedish conditions, no conclusions can be drawn from studies on the effects of arginine-fluoride toothpaste in children. Arginine-containing toothpaste costs about 40% more than basic fluoride toothpaste; to determine whether it is more cost-effective, the higher cost must be considered in relation to any additional caries-preventive effect. The literature review also disclosed some questionable research ethics: in several of the studies, the children in the control group used non-fluoride toothpaste. Toothpaste without fluoride is not as effective against dental caries as the standard treatment - fluoride toothpaste - which has a well -documented effect. This contravenes the fundamental principles of research ethics. Conclusion: At present there is insufficient evidence in support of a caries-preventive effect for the inclusion of arginine in toothpastes. More rigorous studies, and studies which are less dependent on commercial interests, are required. (C) 2016 S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Arginine
- Arginine-fluoride toothpaste
- Caries
- Caries prevention
- Dental care
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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