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Modulation of exper...
Modulation of experimental facial pain via somatosensory stimuli targeting sensations of different valence
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- Taneja, P (författare)
- Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Scandinavian Centre for Orofacial Neurosciences (SCON), Aarhus, Denmark,Aarhus Univ, Denmark; SCON, Denmark
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- Olausson, Håkan (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Neurofysiologiska kliniken US
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- Trulsson, M (författare)
- Karolinska Institutet,SCON, Denmark; Karolinska Inst, Sweden
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- Vase, L (författare)
- Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark,Aarhus Univ, Denmark
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- Svensson, Peter (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON),Aarhus Univ, Denmark; SCON, Denmark; Malmo Univ, Sweden
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- Baad-Hansen, L (författare)
- Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Scandinavian Centre for Orofacial Neurosciences (SCON), Aarhus, Denmark,Aarhus Univ, Denmark; SCON, Denmark
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(creator_code:org_t)
- 2020-04-24
- 2020
- Engelska.
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Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842 .- 0305-182X. ; 47:6, s. 720-730
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Knowledge of pain modulation from orofacial somatosensory stimuli with different valence (pleasant-unpleasant) is limited.OBJECTIVES: To investigate: (1) The modulatory effects of painful, pleasant and unpleasant somatosensory stimuli on 2 models of experimental facial pain, (2) If modulation could be changed by blocking peripheral nerves via application of a local anesthetic: EMLA, or blocking endogenous opioid receptors via naltrexone, (3) If pain ratings were significantly correlated with participant psychological profiles.METHODS: 38 healthy women received experimental facial skin burning pain or jaw myalgia for four randomised sessions on different days. The painful region was stimulated with mechanical or thermal painful, pleasant, unpleasant and control stimuli, with ratings recorded before and during stimulation. Sessions differed in pre-treatment: EMLA/naltrexone/placebo tablet/cream.RESULTS: Significant effects of thermal or mechanical stimuli (P<0.017), but not session (P>0.102), were found on pain ratings for both models. In myalgia, painful cold resulted in a greater reduction in pain ratings than unpleasant cold, pleasant cold, control and pleasant warmth (P<0.004). Decreases in pain ratings from painful, unpleasant and pleasant mechanical stimuli was greater than control (P<0.002). In burning pain, painful cold resulted in a greater reduction in pain ratings than all but one of the other thermal stimuli (P<0.033). The pleasant mechanical stimulus reduced pain ratings more than all other mechanical stimuli (P≤0.003). There were no significant correlations between pain and psychometrics.CONCLUSION: Valence targeted thermal and mechanical stimuli modulated experimental myalgia and skin burning pain (P<0.017). Partially blocking peripheral afferents or opioid receptors did not affect modulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Experimental pain
- myalgia
- nociception
- orofacial pain
- somatosensation
- stimulus
- trigeminal nerve
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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