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Membrane Protein St...
Membrane Protein Structures in Lipid Bilayers; Small-Angle Neutron Scattering With Contrast-Matched Bicontinuous Cubic Phases
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- Conn, Charlotte E (författare)
- RMIT University, Australia
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- de Campo, Liliana (författare)
- Australian Nuclear Science and Technology Organisation
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- Whitten, Andrew E (författare)
- Australian Nuclear Science and Technology Organisation
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- Garvey, Christopher J. (författare)
- Malmö University,Lund University,Lunds universitet,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Australian Nuclear Science and Technology Organisation; Lund Institute for Advanced Neutron and X-Ray Science,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Krause-Heuer, Anwen M (författare)
- Australian Nuclear Science and Technology Organisation
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- van 't Hag, Leonie (författare)
- Monash University, Monash University
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(creator_code:org_t)
- 2021-02-09
- 2020
- Engelska.
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Ingår i: Frontiers in chemistry. - : Frontiers Media S.A.. - 2296-2646. ; 8
- Relaterad länk:
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https://doi.org/10.3...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- . Deuterated vesicles can be used to obtain the radius of gyration of membrane proteins, but protein-protein interference effects within the vesicles severely limits this method such that the protein structure cannot be modeled. We show herein that different membrane protein conformations can be distinguished within the lipid bilayer of the bicontinuous cubic phase using contrast-matching. Time-resolved studies performed using SANS illustrate the complex phase behavior in lyotropic liquid crystalline systems and emphasize the importance of this development. We believe that studying membrane protein structures and phase behavior in contrast-matched lipid bilayers will advance both biological and pharmaceutical applications of membrane-associated proteins, biosensors and food science.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- lipid cubic phase
- membrane protein
- peptide structure
- self-assembly
- small-angle scattering
- lipid cubic phase
- membrane protein
- peptide structure
- self-assembly
- small-angle scattering
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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