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Reverse Iontophoret...
Reverse Iontophoretic Extraction of Skin Cancer-Related Biomarkers
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- Morin, Maxim (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Björklund, Sebastian (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Jankovskaja, Skaidre (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Moore, Kieran (författare)
- Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England.
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- Delgado-Charro, Maria Begona (författare)
- Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England.
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- Ruzgas, Tautgirdas (författare)
- Malmö universitet,Biofilms Research Center for Biointerfaces,Institutionen för biomedicinsk vetenskap (BMV)
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- Guy, Richard H. (författare)
- Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England.
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- Engblom, Johan, 1965- (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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(creator_code:org_t)
- 2021-12-29
- 2022
- Engelska.
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Ingår i: Pharmaceutics. - : MDPI. - 1999-4923. ; 14:1
- Relaterad länk:
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https://doi.org/10.3...
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https://mau.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Non-invasive methods for early diagnosis of skin cancer are highly valued. One possible approach is to monitor relevant biomarkers such as tryptophan (Trp) and kynurenine (Kyn), on the skin surface. The primary aim of this in vitro investigation was, therefore, to examine whether reverse iontophoresis (RI) can enhance the extraction of Trp and Kyn, and to demonstrate how the Trp/Kyn ratio acquired from the skin surface reflects that in the epidermal tissue. The study also explored whether the pH of the receiver medium impacted on extraction efficiency, and assessed the suitability of a bicontinuous cubic liquid crystal as an alternative to a simple buffer solution for this purpose. RI substantially enhanced the extraction of Trp and Kyn, in particular towards the cathode. The Trp/Kyn ratio obtained on the surface matched that in the viable skin. Increasing the receiver solution pH from 4 to 9 improved extraction of both analytes, but did not significantly change the Trp/Kyn ratio. RI extraction of Trp and Kyn into the cubic liquid crystal was comparable to that achieved with simple aqueous receiver solutions. We conclude that RI offers a potential for non-invasive sampling of low-molecular weight biomarkers and further investigations in vivo are therefore warranted.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Farmaceutisk synteskemi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Pharmaceutical Chemistry (hsv//eng)
Nyckelord
- tryptophan
- kynurenine
- tryptophan-to-kynurenine ratio
- cancer-related biomarkers
- non-invasive extraction
- bicontinuous cubic liquid crystals
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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