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Effects of saliva o...
Effects of saliva or serum coating on adherence of Streptococcus oralis strains to titanium
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- Dorkhan, Marjan (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Chávez de Paz, Luis E. (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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Skepö, Marie (författare)
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- Svensäter, Gunnel (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Davies, Julia (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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(creator_code:org_t)
- Society for General Microbiology, 2012
- 2012
- Engelska.
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Ingår i: Microbiology. - : Society for General Microbiology. - 1350-0872 .- 1465-2080. ; 158:2, s. 390-397
- Relaterad länk:
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https://mau.diva-por... (primary) (Raw object)
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https://mau.diva-por...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The use of dental implants to treat tooth loss has increased rapidly over recent years. 'Smooth' implants showing high long-term success rates have successively been replaced by implants with rougher surfaces, designed to stimulate rapid osseointegration and promote tissue healing. If exposed in the oral cavity, rougher surfaces may promote bacterial adhesion leading to formation of microbial biofilms which can induce peri-implant inflammation. Streptococcus oralis is an early colonizer of oral surfaces and has been recovered from titanium surfaces in vivo. The purpose of this study was to examine the adherence of clinical strains of S. oralis to titanium with smooth or moderately rough surface topography and to determine the effect of a saliva- or serum-derived coating on this process. Adherence was studied using a flow-cell system with confocal laser scanning microscopy, while putative adhesins were analysed using proteomics of bacterial cell wall proteins. This showed that adherence to moderately rough was greater than to smooth surfaces. Serum did not promote binding of any studied S. oralis strains to titanium whereas a saliva-coating increased adherence in two of three strains tested. The high level of adherence to the moderately rough surfaces was maintained even in the presence of a saliva coating. The S. oralis strains that bound to saliva expressed an LPXTG-linked protein which was not present in the non-adherent strain. Thus strains of S. oralis differ in their capacity to bind to saliva-coated titanium and we propose that this is due to differential expression of a novel adhesin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
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