Sökning: onr:"swepub:oai:DiVA.org:mau-6496" > Efficacy and safety...
Fältnamn | Indikatorer | Metadata |
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000 | 04480naa a2200757 4500 | |
001 | oai:DiVA.org:mau-6496 | |
003 | SwePub | |
008 | 200228s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-64962 URI |
024 | 7 | a https://doi.org/10.1002/art.277662 DOI |
040 | a (SwePub)mau | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Strietzel, Frank P4 aut |
245 | 1 0 | a Efficacy and safety of an intraoral electrostimulation device for xerostomia relief :b A multicenter randomized trial |
264 | c 2010-12-28 | |
264 | 1 | b Wiley,c 2011 |
338 | a print2 rdacarrier | |
520 | a Objective: The objective of the study was to evaluate the efficacy in treating xerostomia and the safety of an intraoral electrostimulation device, containing stimulating electrodes, an electronic circuit and a power source. The device delivers electrostimulation through the oral mucosa to the lingual nerve, in order to enhance the salivary reflex. Methods: The device was tested on a sample of patients with xerostomia due to Sjögren’s syndrome and other sicca conditions in a prospective randomized multi-center trial consisting of two stages: (I) a double blind, cross-over designed stage to compare the effects of the electrically “active” device with the “sham” device, both used for one month, and (II) a 3- month open label stage to assess the long-term influence of the “active” device. Improvement of xerostomia severity from baseline was the primary outcome. Results: A total of 114 subjects were randomized. In Stage I, “active” device performed better than “sham” for patient-reported xerostomia severity (p<0.002), xerostomia frequency (p<0.05), quality of life impairment (p<0.01) and swallowing difficulty (p<0.02). At the end of Stage II, statistically significant improvements were verified for patient-reported xerostomia severity (p<0.0001), xerostomia frequency (p<0.0001), oral discomfort (p<0.001), speech difficulty (p<0.02) and sleeping difficulty (p<0.001), and for resting salivary flow-rate (p<0.01). Conclusion: Daily use of the device alleviated oral dryness, discomfort and some complications of xerostomia, such as speech and sleeping difficulties, and increased salivary output. The results show a cumulative positive effect of the device over the period of the study, from baseline to the trial’s end. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng |
653 | a xerostomia | |
653 | a dry mouth | |
653 | a salivary gland hypofunction | |
653 | a saliva | |
653 | a electrical stimulation | |
653 | a electrostimulation | |
653 | a Sjögren’s syndrome | |
700 | 1 | a Lafaurie, Gloria I4 aut |
700 | 1 | a Bautista Mendoza, Gloria R4 aut |
700 | 1 | a Alajbeg, Ivan4 aut |
700 | 1 | a Pejda, Slavica4 aut |
700 | 1 | a Vuleti?, Lea4 aut |
700 | 1 | a Mantilla, Rubén4 aut |
700 | 1 | a Falcão, Denise P4 aut |
700 | 1 | a Leal, Soraya C4 aut |
700 | 1 | a Barreto Bezerra, Ana C4 aut |
700 | 1 | a Tran, Simon D4 aut |
700 | 1 | a Ménard, Henri A4 aut |
700 | 1 | a Kimoto, Suguru4 aut |
700 | 1 | a Pan, Shaoxia4 aut |
700 | 1 | a Martín-Granizo, Rafael A4 aut |
700 | 1 | a Maniegas Lozano, M Lourdes4 aut |
700 | 1 | a Zunt, Susan L4 aut |
700 | 1 | a Krushinski, Cheryl A4 aut |
700 | 1 | a Melilli, Dario4 aut |
700 | 1 | a Campisi, Giuseppina4 aut |
700 | 1 | a Paderni, Carlo4 aut |
700 | 1 | a Dolce, Sonia4 aut |
700 | 1 | a Yepes, Juan F4 aut |
700 | 1 | a Lindh, Liselottu Malmö högskola,Odontologiska fakulteten (OD)4 aut0 (Swepub:mau)odlili |
700 | 1 | a Koray, Meltem4 aut |
700 | 1 | a Mumcu, Gonca4 aut |
700 | 1 | a Elad, Sharon4 aut |
700 | 1 | a Zeevi, Itai4 aut |
700 | 1 | a Aldape Barrios, Beatriz C4 aut |
700 | 1 | a López Sánchez, Rodrigo M4 aut |
700 | 1 | a Beiski, Ben Z4 aut |
700 | 1 | a Wolff, Andy4 aut |
700 | 1 | a Konttinen, Yrjö T4 aut |
710 | 2 | a Malmö högskolab Odontologiska fakulteten (OD)4 org |
773 | 0 | t Arthritis and Rheumatismd : Wileyg 63:1, s. 180-190q 63:1<180-190x 0004-3591x 1529-0131 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-6496 |
856 | 4 8 | u https://doi.org/10.1002/art.27766 |
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