onr:"swepub:oai:DiVA.org:mau-69946"
Sökning: onr:"swepub:oai:DiVA.org:mau-69946" > Patient safety of a...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Patient safety of adjunct pre-operative intravenous S-ketamine for pain relief in third molar surgery - a randomised, placebo-controlled, double-blind trial
-
- Eriksson, Lars B. (författare)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden; Uppsala Univ, Ctr Clin Res, Falun, Sweden; Falun Cty Hosp, Dept Oral & Maxillofacial Surg, S-79182 Falun, Sweden
-
- Gordh, Torsten (författare)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
-
- Karlsten, Rolf (författare)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2024
- 2024
- Engelska.
- Ingår i: BRITISH JOURNAL OF PAIN. - : Sage Publications. - 2049-4637.
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Purpose: To study patient safety in third molar surgery, where two different doses of S-ketamine were administered for pain relief and compared to a placebo (saline). The primary focus was capillary oxygen saturation of the blood (SpO(2)) and secondarily, alterations in respiratory rate, blood pressure, pulse or adverse events. Methods: One hundred and sixty-eight subjects were included in a randomised, placebo-controlled, double-blind trial. The two subanaesthetic study drugs were low-dose S-ketamine (0.125 mg/kg) and high-dose S-ketamine (0.25 mg/kg). Every patient was sedated with midazolam prior to infusion of the investigational drug. The teeth were surgically removed according to a routine clinical procedure, under local anaesthesia. Results: Primary end-point for the safety aspects was capillary oxygen saturation (SpO(2)) after administration of the investigational drug was finished. A significant difference was found between the placebo and the high-dose group at that point (p = .021), with a decrease of saturation in the high-dose group. The lowest saturation and the number of registrations of SpO(2) <90% did not show any difference between groups. Oxygen supplementation was given in circa 40% of the cases with no differences between the intervention groups. No other significant differences between groups regarding saturation or respiratory rate were noted. Conclusion: In this study, it was safe to use adjunct preoperative single-dose intravenous S-ketamine 0.25 mg/kg body weight for pain relief, in midazolam-sedated patients receiving third molar surgery. There were no serious adverse events or symptoms of overdose nor any clinically relevant effects on circulatory or respiratory parameters.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Adverse events
- physiological effects
- safety
- S-ketamine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
- BRITISH JOURNAL OF PAIN (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Eriksson, Lars B ...
- Gordh, Torsten
- Karlsten, Rolf
- Thor, Andreas
- Tegelberg, Ake
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Anestesi och int ...
- Artiklar i publikationen
- BRITISH JOURNAL ...
- Av lärosätet
- Malmö universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
