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Sequence variants i...
Sequence variants in toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk
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Sun, J L (författare)
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- Wiklund, F (författare)
- Karolinska Institutet,Umeå universitet,Onkologi
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Zheng, S L (författare)
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Chang, B L (författare)
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- Bälter, Katarina (författare)
- Karolinska Institutet
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Li, L W (författare)
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Johansson, J E (författare)
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Li, G (författare)
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- Adami, H O (författare)
- Karolinska Institutet
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Liu, W N (författare)
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Tolin, A (författare)
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Turner, A R (författare)
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Meyers, D A (författare)
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Isaacs, W B (författare)
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Xu, J F (författare)
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- Gronberg, H (författare)
- Karolinska Institutet,Umeå universitet,Onkologi
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(creator_code:org_t)
- 2005-04-05
- 2005
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA. Umea Univ, Dept Radiat Sci & Oncol, Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Univ Uppsala Hosp, Reg Oncol Ctr, Uppsala, Sweden. Johns Hopkins Sch Med, Dept Urol, Baltimore, MD USA. : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 97:7, s. 525-532
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Background: Chronic inflammation plays an important role in several human cancers and may be involved in the etiology of prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross-talk between innate immunity and adaptive immunity. Our previous finding of an association of TLR4 gene sequence variants and prostate cancer risk provides evidence for a role of TLRs in prostate cancer. In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing within a 54-kb region on 4p14, were associated with prostate cancer risk. Methods: We selected 32 single-nucleotide polymorphisms (SNPs) covering these three genes and genotyped these SNPs in 96 control subjects from the Cancer Prostate in Sweden (CAPS) population-based prostate cancer case-control study. Five distinct haplotype blocks were inferred at this region, and we identified 17 haplotype-tagging SNPs (htSNPs) that could uniquely describe < 95% of the haplotypes. These 17 htSNPs were then genotyped in the entire CAPS study population (1383 case subjects and 780 control subjects). Odds ratios of prostate cancer for the carriers of a variant allele versus those with the wild-type allele were estimated using unconditional logistic regression. Results: The allele frequencies of 11 of the 17 SNPs were statistically significantly different between case and control subjects (P = .04-.001), with odds ratios for variant allele carriers (homozygous or heterozygous) compared with wild-type allele carriers ranging from 1.20 (95% confidence interval [CI] = 1.00 to 1.43) to 1.38 (95% CI = 1.12 to 1.70). Phylogenetic tree analyses of common haplotypes identified a clade of two evolutionarily related haplotypes that are statistically significantly associated with prostate cancer risk. These two haplotypes contain all the risk alleles of these 11 associated SNPs. Conclusion: The observed multiple associated SNPs at the TLR6-TLR1-TLR10 gene cluster were dependent and suggest the presence of a founder prostate cancer risk variant on this haplotype background. The TLR6-TLR1-TLR10 gene cluster may play a role in prostate cancer risk, although further functional studies are needed to pinpoint the disease-associated variants in this gene cluster.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sun, J L
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Wiklund, F
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Zheng, S L
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Chang, B L
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Bälter, Katarina
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Li, L W
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visa fler...
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Johansson, J E
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Li, G
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Adami, H O
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Liu, W N
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Tolin, A
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Turner, A R
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Meyers, D A
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Isaacs, W B
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Xu, J F
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Gronberg, H
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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Journal of the N ...
- Av lärosätet
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Mälardalens universitet
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Umeå universitet
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Karolinska Institutet