A quasi-realistic computational model development and flow field study of the human upper and central airways

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Rezazadeh, M. R.School of Mechanical Engineering, Shiraz University, Shiraz, Iran (författare)

A quasi-realistic computational model development and flow field study of the human upper and central airways

Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

2024
Springer Science and Business Media Deutschland GmbH,2024
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:mdh-66735
https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-66735URI
https://doi.org/10.1007/s11517-024-03117-9DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

The impact of drug delivery and particulate matter exposure on the human respiratory tract is influenced by various anatomical and physiological factors, particularly the structure of the respiratory tract and its fluid dynamics. This study employs computational fluid dynamics (CFD) to investigate airflow in two 3D models of the human air conducting zone. The first model uses a combination of CT-scan images and geometrical data from human cadaver to extract the upper and central airways down to the ninth generation, while the second model develops the lung airways from the first Carina to the end of the ninth generation using Kitaoka’s deterministic algorithm. The study examines the differences in geometrical characteristics, airflow rates, velocity, Reynolds number, and pressure drops of both models in the inhalation and exhalation phases for different lobes and generations of the airways. From trachea to the ninth generation, the average air flowrates and Reynolds numbers exponentially decay in both models during inhalation and exhalation. The steady drop is the case for the average air velocity in Kitaoka’s model, while that experiences a maximum in the 3rd or 4th generation in the quasi-realistic model. Besides, it is shown that the flow field remains laminar in the upper and central airways up to the total flow rate of 15 l/min. The results of this work can contribute to the understanding of flow behavior in upper respiratory tract. Graphical Abstract: (Figure presented.)

Ämnesord och genrebeteckningar

TEKNIK OCH TEKNOLOGIER Maskinteknik hsv//swe
ENGINEERING AND TECHNOLOGY Mechanical Engineering hsv//eng
Computational fluid dynamics (CFD)
Inhalation and Exhalation
Kitaoka’s algorithm
Lung generations
Respiratory tract
Air
Biological organs
Computerized tomography
Drops
Drug delivery
Flow fields
Reynolds number
Air flow-rate
Computational fluid dynamic
Computational modelling
Kitaokum’s algorithm
Lung generation
Model development
Reynold number
S-algorithms
Computational fluid dynamics

Biuppslag (personer, institutioner, konferenser, titlar ...)

Dastan, A.Department of Mechanical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran (författare)
Sadrizadeh, SasanMälardalens universitet,Framtidens energi,Department of Civil and Architectural Engineering, KTH University, Stockholm, Sweden(Swepub:mdh)ssh03 (författare)
Abouali, O.School of Mechanical Engineering, Shiraz University, Shiraz, Iran. Department of Civil and Architectural Engineering, KTH University, Stockholm, Sweden (författare)
School of Mechanical Engineering, Shiraz University, Shiraz, IranDepartment of Mechanical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran (creator_code:org_t)

Sammanhörande titlar

Ingår i:Medical and Biological Engineering and Computing: Springer Science and Business Media Deutschland GmbH0140-01181741-0444

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Medical and Biological Engineering and Computing (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Rezazadeh, M. R.; Dastan, A.; Sadrizadeh, Sasa ...; Abouali, O.

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TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Maskinteknik

Artiklar i publikationen: Medical and Biol ...

Av lärosätet: Mälardalens universitet

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