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Determination of th...
Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems
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- Chudinova, E. (författare)
- National Research Tomsk Polytechnic University, Tomsk, Russian Federation
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- Surmeneva, M. (författare)
- National Research Tomsk Polytechnic University, Tomsk, Russian Federation
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- Koptioug, Andrei, 1956- (författare)
- Mittuniversitetet,Institutionen för kvalitets- och maskinteknik
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- Sokolova, V. (författare)
- University of Duisburg-Essen, Essen, Germany
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- Prymak, O. (författare)
- University of Duisburg-Essen, Essen, Germany
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- Bouckercha, S. (författare)
- University of Duisburg-Essen, Essen, Germany
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- Epple, M. (författare)
- University of Duisburg-Essen, Essen, Germany
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- Surmenev, R. (författare)
- National Research Tomsk Polytechnic University, Tomsk, Russian Federation
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(creator_code:org_t)
- Institute of Physics Publishing (IOPP), 2019
- 2019
- Engelska.
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Ingår i: IOP Conference Series. - : Institute of Physics Publishing (IOPP).
- Relaterad länk:
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https://doi.org/10.1...
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https://miun.diva-po... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
Ämnesord
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)