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Genetic influences ...
Genetic influences on central and peripheral nervous system activity during fear conditioning.
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- Kastrati, Gránit (författare)
- Mittuniversitetet,Institutionen för psykologi och socialt arbete,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden
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- Rosén, Jörgen (författare)
- Mittuniversitetet,Institutionen för psykologi och socialt arbete,Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden
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- Fredrikson, M (författare)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Chen, X (författare)
- Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands
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- Kuja-Halkola, R (författare)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Jensen, K B (författare)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Åhs, Fredrik (författare)
- Mittuniversitetet,Institutionen för psykologi och socialt arbete,Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden
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(creator_code:org_t)
- 2022-03-08
- 2022
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Fear conditioning is an evolutionarily conserved type of learning serving as a model for the acquisition of situationally induced anxiety. Brain function supporting fear conditioning may be genetically influenced, which in part could explain genetic susceptibility for anxiety following stress exposure. Using a classical twin design and functional magnetic resonance imaging, we evaluated genetic influences (h2) on brain activity and standard autonomic measures during fear conditioning. We found an additive genetic influence on mean brain activation (h2 = 0.34) and autonomic responses (h2 = 0.24) during fear learning. The experiment also allowed estimation of the genetic influence on brain activation during safety learning (h2 = 0.55). The mean safety, but not fear, related brain activation was genetically correlated with autonomic responses. We conclude that fear and safety learning processes, both involved in anxiety development, are moderately genetically influenced as expressed both in the brain and the body.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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