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N1-Methylnicotinami...
N1-Methylnicotinamide : Is it Time to Consider it as a Dietary Supplement for Athletes?
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- Nejabati, H. R. (författare)
- Tabriz University of Medical Sciences
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- Ghaffari-Novin, M. (författare)
- Islamic Azad University
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- Fathi-Maroufi, N. (författare)
- Tabriz University of Medical Sciences
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- Faridvand, Yousef (författare)
- Mittuniversitetet,Institutionen för hälsovetenskaper (HOV),Tabriz University of Medical Sciences, Tabriz, Iran
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- Holmberg, Hans-Christer, 1958- (författare)
- Mittuniversitetet,Institutionen för hälsovetenskaper (HOV),University of British Columbia, Vancouver, BC, Canada,Mid Sweden University, Östersund,University of Northern British Columbia
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- Hansson, Ola (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genomik, diabetes och endokrinologi,Patologi, Malmö,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genomics, Diabetes and Endocrinology,Pathology, Malmö
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- Nikanfar, S. (författare)
- Tabriz University of Medical Sciences
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- Nouri, M. (författare)
- Tehran University of Medical Sciences
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(creator_code:org_t)
- Bentham Science Publishers Ltd. 2022
- 2022
- Engelska.
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Ingår i: Current pharmaceutical design. - : Bentham Science Publishers Ltd.. - 1381-6128 .- 1873-4286. ; 28:10, s. 800-805
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Exercise is considered to be a “medicine” due to its modulatory roles in metabolic disorders, such as diabetes and obesity. The intensity and duration of exercise determine the mechanism of energy production by various tissues of the body, especially by muscles, in which the requirement for adenosine triphosphate (ATP) increases by as much as 100-fold. Naturally, athletes try to improve their exercise performance by dietary supplementation with, e.g., vitamins, metabolites, and amino acids. MNAM, as a vitamin B3 metabolite, reduc-es serum levels and liver contents of triglycerides and cholesterol, and induces lipolysis. It stimulates gluconeo-genesis and prohibits liver cholesterol and fatty acid synthesis through the expression of sirtuin1 (SIRT1). It seems that MNAM is not responsible for the actions of NNMT in the adipose tissues as MNAM inhibits the activity of NNMT in the adipose tissue and acts as an inhibitor of its activity. NNMT-MNAM axis is more activated in the muscles of individuals undergoing the high-volume-low-intensity exercise and caloric restriction. Therefore, MNAM could be an important myokine during exercise and fasting where it provides the required energy for muscles through the induction of lipolysis and gluconeogenesis in the liver and adipose tissues, respectively. Increased levels of MNAM in exercise and fasting led us to propose that the consumption of MNAM during training, especially endurance training, could boost exercise capacity and improve perfor-mance. Therefore, in this review, we shed light on the potential of MNAM as a dietary supplement in sports medicine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- dietary supplement
- exercise
- MNAM
- myokine
- sports medicine
- vitamin B3
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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