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Sequence Transposit...
Sequence Transpositions Restore Genes on the HighlyDegenerated W Chromosomes of Songbirds
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Xu, Luohao (författare)
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- Irestedt, Martin, 1966- (författare)
- Naturhistoriska riksmuseet,Enheten för bioinformatik och genetik
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Zhou, Qi (författare)
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(creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: Genes. - 2073-4425. ; 11
- Relaterad länk:
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https://doi.org/10.3...
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visa fler...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The female-specific W chromosomes of most Neognathae birds are highly degenerated and gene-poor. Previous studies have demonstrated that the gene repertoires of the Neognathae bird W chromosomes, despite being in small numbers, are conserved across bird species, likely due to purifying selection maintaining the regulatory and dosage-sensitive genes. Here we report the discovery of DNA-based sequence duplications from the Z to the W chromosome in birds-of-paradise (Paradisaeidae, Passeriformes), through sequence transposition. The original transposition involved nine genes, but only two of them (ANXA1 and ALDH1A1) survived on the W chromosomes. Both ANXA1 and ALDH1A1 are predicted to be dosage-sensitive, and the expression of ANXA1 is restricted to ovaries in all the investigated birds. These analyses suggest the newly transposed gene onto the W chromosomes can be favored for their role in restoring dosage imbalance or through female-specific selection. After examining seven additional songbird genomes, we further identified five other transposed genes on the W chromosomes of Darwin’s finches and one in the great tit, expanding the observation of the Z-to-W transpositions to a larger range of bird species, but not all transposed genes exhibit dosage-sensitivity or ovary-biased expression We demonstrate a new mechanism by which the highly degenerated W chromosomes of songbirds can acquire genes from the homologous Z chromosomes, but further functional investigations are needed to validate the evolutionary forces underlying the transpositions
Nyckelord
- Ecosystems and species history
- Ekosystem och arthistoria
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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