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  • Österroos, AlbinUppsala universitet,Uppsala University,Uppsala Univ, Sweden,Hematologi (författare)

A risk score based on real-world data to predict early death in acute promyelocytic leukemia

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-01-27
  • Ferrata Storti Foundation,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-100340
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-100340URI
  • https://doi.org/10.3324/haematol.2021.280093DOI
  • https://lup.lub.lu.se/record/4c4b2a38-be26-4935-b91b-39252f6e9813URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187471URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481758URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150179586URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agency:Regionalt Cancercentrum Syd
  • Funding Agencies|Swedish Association of Local Authorities and Regions; Swedish Cancer Society; Region Skane; Regionalt Cancercentrum Syd
  • With increasingly effective treatments, early death (ED) has become the predominant reason for therapeutic failure in patients with acute promyelocytic leukemia (APL). To better prevent ED, patients with high-risk of ED must be identified. Our aim was to develop a score that predicts the risk of ED in a real-life setting. We used APL patients in the population based Swedish AML Registry (n=301) and a Portuguese hospital-based registry (n=129) as training and validation cohorts, respectively. The cohorts were comparable with respect to age (median, 54 and 53 years) and ED rate (19.6% and 18.6%). The score was developed by logistic regression analyses, risk-per-quantile assessment and scoring based on ridge regression coefficients from multivariable penalized logistic regression analysis. White blood cell count, platelet count and age were selected by this approach as the most significant variables for predicting ED. The score identified low-, high-and very high-risk patients with ED risks of 4.8%, 20.2% and 50.9% respectively in the training cohort and with 6.7%, 25.0% and 36.0% as corresponding values for the validation cohort. The score identified an increased risk of ED already at sub-normal and normal white blood cell counts and, consequently, it was better at predicting ED risk than the Sanz score (AUROC 0.77 vs. 0.64). In summary, we here present an externally validated and population-based risk score to predict ED risk in a real-world setting, identifying patients with the most urgent need of aggressive ED prevention. The results also suggest that increased vigilance for ED is already necessary at sub-normal/normal white blood cell counts.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Maia, TâniaDepartment of Clinical Hematology, University Hospital Center of São João, Porto, Portugal,Univ Hosp Ctr Sao Joao, Dept Clin Hematol, Porto, Portugal. (författare)
  • Eriksson, Anna,1977-Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Hematologi(Swepub:uu)anner268 (författare)
  • Jädersten, MartinKarolinska Institutet (författare)
  • Lazarevic, VladimirLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Hematol, Lund, Sweden.;Lund Univ, Stem Cell Ctr, Dept Hematol, Dept Lab Med, Lund, Sweden.(Swepub:lu)med-lzv (författare)
  • Wennström, LovisaDepartment of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden. (författare)
  • Antunovic, PetarLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.(Swepub:liu)petan27 (författare)
  • Cammenga, JörgLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.(Swepub:liu)jorca02 (författare)
  • Deneberg, StefanKarolinska Institutet (författare)
  • Lorenz, FryderykDepartment of Hematology, Norrland University Hospital, Umeå, Sweden,Norrland Univ Hosp, Dept Hematol, Umeå, Sweden. (författare)
  • Möllgård, LarsDepartment of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden. (författare)
  • Uggla, Bertil,1962-Örebro universitet,Institutionen för medicinska vetenskaper,Division of Hematology,Örebro University Hospital,Örebro Univ Hosp, Dept Med, Div Hematol, Örebro, Sweden.(Swepub:oru)bua (författare)
  • Ölander, EmmaDepartment of Hematology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Hematol, Sundsvall, Sweden. (författare)
  • Aguiar, ElianaDepartment of Clinical Hematology, University Hospital Center of São João, Porto, Portugal,Univ Hosp Ctr Sao Joao, Dept Clin Hematol, Porto, Portugal. (författare)
  • Trigo, FernandaDepartment of Clinical Hematology, University Hospital Center of São João, Porto, Portugal,Univ Hosp Ctr Sao Joao, Dept Clin Hematol, Porto, Portugal. (författare)
  • Höglund, MartinUppsala universitet,Uppsala University,Uppsala Univ, Sweden,Hematologi(Swepub:uu)martinhl (författare)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Skane Univ Hosp, Dept Hematol, Lund, Sweden.;Lund Univ, Stem Cell Ctr, Dept Hematol, Dept Lab Med, Lund, Sweden.(Swepub:lu)stem-gju (författare)
  • Lehmann, SörenUppsala universitet,Uppsala University,Karolinska University Hospital,Uppsala Univ, Sweden; Karolinska Univ Hosp, Sweden,Hematologi,Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden.(Swepub:uu)sorle534 (författare)
  • Uppsala UniversityUppsala Univ, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Haematologica: Ferrata Storti Foundation107:7, s. 1528-15370390-60781592-8721

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