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Potential Modulatio...
Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation-A Randomized, Placebo-Controlled Trial
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- Tingö, Lina, 1984- (författare)
- Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden,Nutrition-Gut-Brain Interactions Research Centre,Avdelningen för inflammation och infektion,Medicinska fakulteten,Orebro Univ, Sweden; Orebro Univ, Sweden
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- Hutchinson, Ashley N., 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre,Orebro Univ, Sweden
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- Bergh, Cecilia, 1972- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Stiefvatter, Lena (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Schweinlin, Anna (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Jensen, Morten G. (författare)
- GSK Consumer Healthcare ApS, Vallensbæk Strand, Denmark
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- Krüger, Kirsten (författare)
- Human Nutrition & Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, The Netherland,Wageningen Univ & Res, Netherlands
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- Bischoff, Stephan C. (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre,Orebro Univ, Sweden; Orebro Univ, Sweden
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(creator_code:org_t)
- 2022-09-27
- 2022
- Engelska.
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 14:19
- Relaterad länk:
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0-73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- RCT
- chronic low-grade inflammation
- elderly
- hs-CRP
- n-3 PUFA
- omega-3
- probiotics
- short-chain fatty acids
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Tingö, Lina, 198 ...
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Hutchinson, Ashl ...
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Bergh, Cecilia, ...
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Stiefvatter, Len ...
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Schweinlin, Anna
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Jensen, Morten G ...
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Krüger, Kirsten
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Bischoff, Stepha ...
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Brummer, Robert ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Nutrients
- Av lärosätet
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Örebro universitet
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Linköpings universitet