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Sökning: onr:"swepub:oai:DiVA.org:oru-102484" > Cancer risk in pati...

  • Ma, WenjieClinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA,Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA. (författare)

Cancer risk in patients with diverticular disease : A nationwide cohort study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022
  • Oxford University Press,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-102484
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102484URI
  • https://doi.org/10.1093/jnci/djac190DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497356URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151210939URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:MGH Executive Committee on Research Tosteson and Fund for Medical Discovery Postdoctoral Fellowship AwardAmerican Gastroenterological Association Research Scholar Award AGA2021-13-01United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA R01 DK101495  Stuart and Suzanne Steele MGH Research Scholar Award
  • Background: There are little data on diverticular disease and cancer development other than colorectal cancer.Methods: We conducted a population-based, matched cohort study with linkage of nationwide registers to the Epidemiology Strengthened by histoPathology Reports in Sweden histopathology cohort. We included 75 704 patients with a diagnosis of diverticular disease and colorectal histopathology and 313 480 reference individuals from the general population matched on age, sex, calendar year, and county. Cox proportional hazards models estimated multivariable-adjusted hazard ratios (HRs) for associations between diverticular disease and overall cancer and specific cancers.Results: Over a median follow-up of 6 years, we documented 12 846 incident cancers among patients with diverticular disease and 43 354 incident cancers among reference individuals from the general population. Compared with reference individuals, patients with diverticular disease had statistically significantly increased overall cancer incidence (24.5 vs 18.1 per 1000 person-years), equivalent to 1 extra cancer case in 16 individuals with diverticular disease followed-up for 10 years. After adjusting for covariates, having a diagnosis of diverticular disease was associated with a 33% increased risk of overall cancer (95% confidence interval [CI] = 1.31 to 1.36). The risk increases also persisted compared with siblings as secondary comparators (HR = 1.26, 95% CI = 1.21 to 1.32). Patients with diverticular disease also had an increased risk of specific cancers, including colon cancer (HR = 1.71, 95% CI = 1.60 to 1.82), liver cancer (HR = 1.72, 95% CI = 1.41 to 2.10), pancreatic cancer (HR = 1.62, 95% CI = 1.42 to 1.84), and lung cancer (HR = 1.50, 95% CI = 1.39 to 1.61). The increase in colorectal cancer risk was primarily restricted to the first year of follow-up, and especially early cancer stages.Conclusions: Patients with diverticular disease who have colorectal histopathology have an increased risk of overall incident cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Walker, Marjorie M.Department of Anatomical Pathology, Faculty of Health and Medicine, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia,Univ Newcastle, Coll Hlth Med & Wellbeing, Fac Hlth & Med, Dept Anat Pathol, Newcastle, NSW, Australia. (författare)
  • Thuresson, MarcusStatisticon AB, Uppsala, Sweden. (författare)
  • Roelstraete, BjornDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (författare)
  • Sköldberg, FilipUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)filipsb (författare)
  • Olén, OlaKarolinska Institutet (författare)
  • Strate, Lisa L.Division of Gastroenterology, University of Washington, Seattle WA, USA,Univ Washington, Div Gastroenterol, Seattle, WA 98195 USA. (författare)
  • Chan, Andrew T.Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston MA, USA; Cancer Center, Massachusetts General Hospital, Boston MA, USA,Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA.;Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02114 USA. (författare)
  • Ludvigsson, Jonas F.,1969-Karolinska Institutet(Swepub:oru)jsln (författare)
  • Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USAMassachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the National Cancer Institute: Oxford University Press0027-88741460-2105

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