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Lifestyle factors f...
Lifestyle factors for the prevention of inflammatory bowel disease
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- Lopes, Emily W. (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
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- Chan, Simon S. M. (författare)
- Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK; Norwich Medical School, University of East Anglia, Norwich, UK,Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Gastroenterol, Norwich, Norfolk, England.;Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Harvard Univ TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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- Song, Mingyang (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USA; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Pediatrics, Örebro universitet, Örebro, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Örebro Univ, Dept Pediat, Örebro, Sweden.
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- Håkansson, Niclas (författare)
- Karolinska Institutet
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- Lochhead, Paul (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
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- Clark, Allan (författare)
- Norwich Medical School, University of East Anglia, Norwich, UK,Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
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- Burke, Kristin E. (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
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- Ananthakrishnan, Ashwin N. (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
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- Cross, Amanda J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Cancer Screening & Prevention Research Group, Department of Surgery & Cancer, Imperial College London, London, UK,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Dept Surg & Canc, Canc Screening & Prevent Res Grp, London, England.
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy,Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy.
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- Bergmann, Manuela M. (författare)
- Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany,German Inst Human Nutr Potsdam Rehbrucke, Epidemiol, Nuthetal, Germany.
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- Richter, James M. (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
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- Chan, Andrew T. (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Brigham & Womens Hosp, Charming Div Network Med, Boston, MA 02115 USA.
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- Olén, Ola (författare)
- Karolinska Institutet
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Khalili, Hamed (författare)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USAg; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA; Broad Institute, of MIT and Harvard, Cambridge, MA, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
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EPIC-IBD investigators, - (bidragsgivare)
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Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA. (creator_code:org_t)
- 2022-12-06
- 2023
- Engelska.
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Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 72:6, s. 1093-1100
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.DESIGN: In a prospective cohort study of US adults from the Nurses' Health Study (NHS; n=72 290), NHSII (n=93 909) and Health Professionals Follow-up Study (HPFS; n=41 871), we created modifiable risk scores (MRS; 0-6) for CD and UC based on established lifestyle risk factors, and healthy lifestyle scores (HLS; 0-9) derived from American healthy lifestyle recommendations. We calculated the population attributable risk by comparing the incidence of CD and UC between low-risk (CD-MRS≤1, UC-MRS≤2, HLS≥7) and high-risk groups. We externally validated our findings in three European cohorts: the Swedish Mammography Cohort (n=37 275), Cohort of Swedish Men (n=40 810) and European Prospective Investigation into Cancer and Nutrition (n=404 144).RESULTS: Over 5 117 021 person-years of follow-up (NHS, HPFS: 1986-2016; NHSII: 1991-2017), we documented 346 CD and 456 UC cases. Adherence to a low MRS could have prevented 42.9% (95% CI 12.2% to 66.1%) of CD and 44.4% (95% CI 9.0% to 69.8%) of UC cases. Similarly, adherence to a healthy lifestyle could have prevented 61.1% (95% CI 16.8% to 84.9%) of CD and 42.2% (95% CI 1.7% to 70.9%) of UC cases. In our validation cohorts, adherence to a low MRS and healthy lifestyle could have, respectively, prevented 43.9%-51.2% and 48.8%-60.4% of CD cases and 20.6%-27.8% and 46.8%-56.3% of UC cases.CONCLUSIONS: Across six US and European cohorts, a substantial burden of inflammatory bowel diseases risk may be preventable through lifestyle modification.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Crohn's disease
- diet
- epidemiology
- ulcerative colitis
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- Av författaren/redakt...
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Lopes, Emily W.
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Chan, Simon S. M ...
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Song, Mingyang
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Ludvigsson, Jona ...
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Håkansson, Nicla ...
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Lochhead, Paul
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visa fler...
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Clark, Allan
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Burke, Kristin E ...
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Ananthakrishnan, ...
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Cross, Amanda J.
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Palli, Domenico
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Bergmann, Manuel ...
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Richter, James M ...
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Chan, Andrew T.
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Olén, Ola
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Wolk, Alicja
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Khalili, Hamed
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EPIC-IBD investi ...
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Örebro universitet
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Uppsala universitet
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Karolinska Institutet