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Serum N-Glycomic Bi...
Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease
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- Shubhakar, Archana (författare)
- Ludger Ltd, Culham Science Centre, Abingdon, Oxfordshire, United Kingdom; Division of BioAnalytical Chemistry, VU University Amsterdam, Amsterdam, The Netherlands
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- Jansen, Bas C (författare)
- Ludger Ltd, Culham Science Centre, Abingdon, Oxfordshire, United Kingdom
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- Adams, Alex T. (författare)
- Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom
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- Reiding, Karli R. (författare)
- Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands; Division of Biomolecular Mass Spectrometry and Proteomics, Utrecht University, Utrecht, The Netherlands
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- Ventham, Nicholas T. (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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- Kalla, Rahul (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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- Bergemalm, Daniel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Urbanowicz, Paulina A (författare)
- Ludger Ltd, Culham Science Centre, Abingdon, Oxfordshire, United Kingdom
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- Gardner, Richard A. (författare)
- Ludger Ltd, Culham Science Centre, Abingdon, Oxfordshire, United Kingdom
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- Wuhrer, Manfred (författare)
- Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Satsangi, Jack (författare)
- Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom
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- Fernandes, Daryl L. (författare)
- Ludger Ltd, Culham Science Centre, Abingdon, Oxfordshire, United Kingdom
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- Spencer, Daniel I. R. (författare)
- Ludger Ltd, Culham Science Centre, Abingdon, Oxfordshire, United Kingdom
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IBD-BIOM Consortium, - (bidragsgivare)
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(creator_code:org_t)
- 2023-01-24
- 2023
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 17:6, s. 919-932
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biomarkers to guide clinical decision-making at diagnosis of inflammatory bowel disease (IBD) are urgently needed. We investigated a composite serum N-glycomic biomarker to predict future disease course in a discovery cohort of 244 newly diagnosed IBD patients. Forty-seven individual glycan peaks were analysed using ultra-high performance liquid chromatography identifying 105 glycoforms from which 24 derived glycan traits were calculated. Multivariable logistic regression was performed to determine associations of derived glycan traits with disease. Cox proportional hazard models were used to predict treatment escalation from first-line treatment to biologics or surgery (hazard ratio (HR) 25.9, p=1.1×10-12; 95% confidence interval (CI), 8.52-78.78). Application to an independent replication cohort of 54 IBD patients yielded a HR of 5.1 (p=1.1×10-5; 95% CI, 2.54-10.1). These data demonstrate the prognostic capacity of serum N-glycan biomarkers and represent a step towards personalized medicine in IBD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Biomarker
- Crohn's disease
- N-Glycans
- Personalised treatment
- Prognosis
- Ulcerative colitis
Publikations- och innehållstyp
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Till lärosätets databas
- Av författaren/redakt...
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Shubhakar, Archa ...
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Jansen, Bas C
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Adams, Alex T.
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Reiding, Karli R ...
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Ventham, Nichola ...
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Kalla, Rahul
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Bergemalm, Danie ...
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Urbanowicz, Paul ...
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Gardner, Richard ...
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Wuhrer, Manfred
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Halfvarson, Jona ...
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Satsangi, Jack
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Fernandes, Daryl ...
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Spencer, Daniel ...
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IBD-BIOM Consort ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Journal of Crohn ...
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Örebro universitet