In utero exposure to ADHD medication and long-term offspring outcomes

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In utero exposure to ADHD medication and long-term offspring outcomes

Bang Madsen, Kathrine (författare): NCRR - National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark

Robakis, Thalia K. (författare): Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Liu, Xiaoqin (författare): NCRR - National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark

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Momen, Natalie (författare): NCRR - National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark

Larsson, Henrik, 1975- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Dreier, Julie Werenberg (författare): NCRR - National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; Department of Clinical Medicine, University of Bergen, Bergen, Norway

Kildegaard, Helene (författare): Hans Christian Andersen's Children's Hospital, Odense University Hospital, Odense, Denmark; Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark

Groth, Jane Bjerg (författare): Department of Otorhinolaryngology and Audiology, Zealand University Hospital, Universty of Copenhagen, Køge, Denmark

Newcorn, Jeffrey H. (författare): Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Hove Thomsen, Per (författare): Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Research Center at the Department for Child- and Adolescent Psychiatry, Aarhus University Hospital, Skejby, Denmark

Munk-Olsen, Trine (författare): NCRR - National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; Research Unit of Psychiatry, Institute for Clinical Research, University of Southern Denmark, Odense, Denmark

Bergink, Veerle (författare): Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

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2023-02-09
2023
Engelska.
Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 28:4, s. 1739-1746

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Attention Deficit Hyperactivity Disorder (ADHD) medication is increasingly being used during pregnancy. Concerns have been raised as to whether ADHD medication has long-term adverse effects on the offspring. The authors investigated whether in utero exposure to ADHD medication was associated with adverse long-term neurodevelopmental and growth outcomes in offspring. The population-based cohort study in the Danish national registers included 1,068,073 liveborn singletons from 1998 to 2015 followed until any developmental diagnosis, death, emigration, or December 31, 2018. Children of mothers who continued ADHD medication (methylphenidate, amphetamine, dexamphetamine, lisdexamphetamine, modafinil, atomoxetine, clonidine) during pregnancy and children of mothers who discontinued ADHD medication before pregnancy were compared using Cox regression. Main outcomes were neurodevelopmental psychiatric disorders, impairments in vision or hearing, epilepsy, seizures, or growth impairment during childhood or adolescence. In total, 898 children were exposed to ADHD medication during pregnancy compared to 1270 children whose mothers discontinued ADHD medication before pregnancy. After adjustment for demographic and psychiatric characteristics of the mother, no increased risk of any offspring developmental disorders was found combined (aHR 0.97, 95% CI 0.81 to 1.17) or for separate subcategories. Similarly, no increased risk was found for any sub-categories of outcomes in the negative control or sibling controlled analyses. Neurodevelopment and growth in offspring do not differ based on antenatal exposure to ADHD medication. These findings provide reassurance for women with ADHD who depend on ADHD medication for daily functioning and who consider continuing medication in pregnancy.

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Av författaren/redakt...: Bang Madsen, Kat ...; Robakis, Thalia ...; Liu, Xiaoqin; Momen, Natalie; Larsson, Henrik, ...; Dreier, Julie We ...; visa fler...; Kildegaard, Hele ...; Groth, Jane Bjer ...; Newcorn, Jeffrey ...; Hove Thomsen, Pe ...; Munk-Olsen, Trin ...; Bergink, Veerle; visa färre...

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In utero exposure to ADHD medication and long-term offspring outcomes

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