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Response to electro...
Response to electroconvulsive therapy in treatment-resistant depression : nationwide observational follow-up study
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- Nygren, Adam (författare)
- Karolinska Institutet
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- Reutfors, Johan (författare)
- Karolinska Institutet
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- Brandt, Lena (författare)
- Centre for Pharmacoepidemiology, Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Sweden,Karolinska Inst, Ctr Pharmacoepidemiol, Dept Med, Div Clin Epidemiol, Solna, Sweden.
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- Bodén, Robert, 1973- (författare)
- Uppsala universitet,Psykiatri
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- Nordenskjöld, Axel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Sweden,Örebro Univ, Univ Hlth Care Res Ctr, Fac Med & Hlth, Örebro, Sweden.
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- Tiger, Mikael (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2023-02-14
- 2023
- Engelska.
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Ingår i: BJPsych Open. - : Royal College of Psychiatrists. - 2056-4724. ; 9:2
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Previous studies have not investigated response rates after electroconvulsive therapy (ECT) in patients with non-psychotic treatment-resistant depression (TRD).AIMS: To assess and compare the response rate of ECT for patients with TRD and non-TRD, in a large and clinically representative patient sample.METHOD: Patients aged ≥18 years, who were treated for a unipolar, non-psychotic depressive episode with at least one ECT session as part of a first-time, index ECT series between 1 January 2011 and 31 December 2017 were included from the Swedish National Quality Register for ECT. Patients who had initiated a third consecutive trial of antidepressants or add-on medications before start of ECT were classified as having TRD. Patients not meeting criteria for TRD were classified as non-TRD. The main outcome was response to ECT according to the Clinical Global Impressions - Improvement Scale (CGI-I), scored as 1 or 2 ('very much' or 'much improved' after ECT, respectively). Logistic regression was used to compare outcome measures between TRD and non-TRD, adjusting for potential confounders.RESULTS: A total of 4244 patients were included. Of these, 1121 patients had TRD and 3123 patients had non-TRD. The CGI-I response rate was 65.9% in the TRD group compared with 75.9% in the non-TRD group (adjusted odds ratio 0.64, 95% CI 0.54-0.75). Older age and more severe depression were predictors of response in patients with TRD.CONCLUSIONS: A clear majority of patients with TRD, as well as patients with non-TRD, responded to ECT, although the response rate was somewhat lower for TRD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Depressive disorders
- antidepressants
- electroconvulsive therapy
- epidemiology
- outcome studies
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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