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Risk factors for im...
Risk factors for impaired respiratory function post COVID-19 : A prospective cohort study of nonhospitalized and hospitalized patients
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- Björsell, Tove (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Infectious Diseases, Karlstad Hospital, Karlstad, Sweden; Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden
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- Sundh, Josefin (författare)
- Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Lange, Anna, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Ahlm, Clas, 1956- (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Forsell, Mattias N. E. (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Tevell, Staffan, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Karlstad Hospital, Karlstad, Sweden; Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden; Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden
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- Blomberg, Anders, 1961- (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Edin, Alicia, 1985- (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Normark, Johan (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Cajander, Sara, 1980- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- 2023-02-23
- 2023
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell Publishing Inc.. - 0954-6820 .- 1365-2796. ; 293:5, s. 600-614
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Severe COVID-19 increases the risk for long-term respiratory impairment, but data after mild COVID-19 are scarce. Our aims were to determine risk factors for reduced respiratory function 3-6 months after COVID-19 infection and to investigate if reduced respiratory function would relate to impairment of exercise performance and breathlessness.METHODS: Patients with COVID-19 were enrolled at the University Hospitals of Umeå and Örebro, and Karlstad Central Hospital, Sweden. Disease severity was defined as mild (nonhospitalized), moderate (hospitalized with or without oxygen treatment), and severe (intensive care). Spirometry, including diffusion capacity (DLCO ), was performed 3-6 months after hospital discharge or study enrollment (for nonhospitalized patients). Breathlessness (defined as ≥1 according to the modified Medical Research Council scale) and functional exercise capacity (1-min sit-to-stand test; 1-MSTST) were assessed.RESULTS: Between April 2020 and May 2021, 337 patients were enrolled in the study. Forced vital capacity and DLCO were significantly lower in patients with severe COVID-19. Among hospitalized patients, 20% had reduced DLCO , versus 4% in nonhospitalized. Breathlessness was found in 40.6% of the participants and was associated with impaired DLCO . A pathological desaturation or heart rate response was observed in 17% of participants during the 1-MSTST. However, this response was not associated with reduced DLCO .CONCLUSION: Reduced DLCO was the major respiratory impairment 3-6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Nyckelord
- COVID-19
- breathlessness
- diffusion capacity
- post-acute COVID-19 syndrome
- spirometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Björsell, Tove
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Sundh, Josefin
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Lange, Anna, 197 ...
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Ahlm, Clas, 1956 ...
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Forsell, Mattias ...
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Tevell, Staffan, ...
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visa fler...
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Blomberg, Anders ...
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Edin, Alicia, 19 ...
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Normark, Johan
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Cajander, Sara, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
- Artiklar i publikationen
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Journal of Inter ...
- Av lärosätet
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Örebro universitet
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Umeå universitet