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Immunotoxicological...
Immunotoxicological effects of perfluorooctanesulfonic acid on European seabass are reduced by polyethylene microplastics
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- Espinosa-Ruiz, Cristóbal (författare)
- Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain
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- González-Fernández, Carmen (författare)
- Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain; INRAE, UR RiverLy, Laboratoire d'écotoxicologie, F-69625, Villeurbanne, France
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- Cormier, Bettie (författare)
- School of Science and Technology, Örebro University, Örebro, Sweden; Department of Biology, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway,Man-Technology-Environment Research Centre (MTM)
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- Keiter, Steffen H., 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,School of Science and Technology, Örebro University, Örebro, Sweden,Man-Technology-Environment Research Centre (MTM)
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- Vieira, Luis R. (författare)
- ICBAS-UP - School of Medicine and Biomedical Sciences, University of Porto, Department of Populations Study, Laboratory of Ecotoxicology and Ecology (ECOTOX), Rua de Jorge Viterbo Ferreira, 228, Porto 4050-313, Portugal; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Terminal de Cruzeiros do Porto de Leixões, 4450-208, Portugal
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- Guilhermino, Lúcia (författare)
- ICBAS-UP - School of Medicine and Biomedical Sciences, University of Porto, Department of Populations Study, Laboratory of Ecotoxicology and Ecology (ECOTOX), Rua de Jorge Viterbo Ferreira, 228, Porto 4050-313, Portugal; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Terminal de Cruzeiros do Porto de Leixões, 4450-208, Portugal
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- Clérandeau, Christelle (författare)
- Université de Bordeaux, UMR 5805 EPOC, 33400, Talence, France
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- Cachot, Jérôme (författare)
- Université de Bordeaux, UMR 5805 EPOC, 33400, Talence, France
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- Esteban, María A. (författare)
- Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain
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- Cuesta, Alberto (författare)
- Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Fish and Shellfish Immunology. - : Elsevier. - 1050-4648 .- 1095-9947. ; 137
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Marine environments receive plastic waste, where it suffers a transformation process into smaller particles. Among them, microplastics (MPs; <5 mm) are ingested by aquatic organisms leading to negative effects on animal welfare. The interactions between MPs, contaminants and organisms are poorly understood. To clarify this issue, European seabass (Dicentrarchus labrax L.) were fed with diets supplemented with 0 (control), polyethylene (PE) MPs (100 mg/kg diet), perfluorooctanesulfonic acid (PFOS, 4.83 μg/kg diet) or PFOS adsorbed to MPs (MPs-PFOS; final concentrations of 4.83 μg and 100 mg of PFOS and MP per kg of feed, respectively). Samples of skin mucus, serum, head-kidney (HK), liver, muscle, brain and intestine were obtained. PFOS levels were high in the liver of fish fed with the PFOS-diet, and markedly reduced when adsorbed to MPs. Compared to the control groups, liver EROD activity did not show any significant changes, whereas brain and muscle cholinesterase activities were decreased in all the groups. The histological and morphometrical study on liver and intestine showed significant alterations in fish fed with the experimental diets. At functional level, all the experimental diets affected the humoral (peroxidase, IgM, protease and bactericidal activities) as well as cellular (phagocytosis, respiratory burst and peroxidase) activities of HK leukocytes, being more marked those effects caused by the PFOS diet. Besides, treatments produced inflammation and oxidative stress as evidenced at gene level. Principal component analysis demonstrated that seabass fed with MPs-PFOS showed more similar effects to MPs alone than to PFOS. Overall, seabass fed with MPs-PFOS diet showed similar or lower toxicological alterations than those fed with MPs or PFOS alone demonstrating the lack of additive effects or even protection against PFOS toxicity.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- European seabass
- Immunity
- Microplastics
- Oxidative stress
- PFOS
- Polyethylene
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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