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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04117naa a2200409 4500 | |
| 001 | oai:DiVA.org:oru-105865 | |
| 003 | SwePub | |
| 008 | 230508s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1058652 URI |
| 024 | 7 | a https://doi.org/10.3389/fimmu.2023.11784342 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Alijagic, Andi,d 1992-u Örebro universitet,Institutionen för naturvetenskap och teknik,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)aiac |
| 245 | 1 0 | a NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity |
| 264 | 1 | b Frontiers Media S.A.c 2023 |
| 338 | a print2 rdacarrier | |
| 520 | a Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly investigated particulates, MNPs may penetrate epithelial barriers, potentially triggering a cascade of signaling events leading to cell damage and inflammation. Inflammasomes are intracellular multiprotein complexes and stimulus-induced sensors critical for mounting inflammatory responses upon recognition of pathogen- or damage-associated molecular patterns. Among these, the NLRP3 inflammasome is the most studied in terms of activation via particulates. However, studies delineating the ability of MNPs to affect NLRP3 inflammasome activation are still rare. In this review, we address the issue of MNPs source and fate, highlight the main concepts of inflammasome activation via particulates, and explore recent advances in using inflammasome activation for assessment of MNP immunotoxicity. We also discuss the impact of co-exposure and MNP complex chemistry in potential inflammasome activation. Development of robust biological sensors is crucial in order to maximize global efforts to effectively address and mitigate risks that MNPs pose for human health. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a Human health | |
| 653 | a inflammation | |
| 653 | a innate immunity | |
| 653 | a plastics | |
| 653 | a pollution | |
| 700 | 1 | a Hedbrant, Alexander,c Ph.D,d 1987-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)arht |
| 700 | 1 | a Persson, Alexander,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)axpn |
| 700 | 1 | a Larsson, Maria,d 1975-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)miln |
| 700 | 1 | a Engwall, Magnus,d 1965-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)mel |
| 700 | 1 | a Särndahl, Eva,d 1963-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)easl |
| 710 | 2 | a Örebro universitetb Institutionen för naturvetenskap och teknik4 org |
| 773 | 0 | t Frontiers in Immunologyd : Frontiers Media S.A.g 14q 14x 1664-3224 |
| 856 | 4 | u https://doi.org/10.3389/fimmu.2023.1178434y Fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105865 |
| 856 | 4 8 | u https://doi.org/10.3389/fimmu.2023.1178434 |
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