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Long-term outcomes ...
Long-term outcomes of vedolizumab in inflammatory bowel disease : the Swedish prospective multicentre SVEAH extension study
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- Visuri, Isabella, 1991- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Eriksson, Carl, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Orebro Univ, Sweden; Karolinska Inst, Sweden
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- Karlqvist, Sara, 1992- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Lykiardopoulos, Byron (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Karlén, Per (författare)
- Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden,Danderyd Hosp, Sweden
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- Grip, Olof (författare)
- Department of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden,Skane Univ Hosp, Sweden
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- Söderman, Charlotte (författare)
- Karolinska Institutet,St Goran Hosp, Sweden
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- Almer, Sven (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Hertervig, Erik (författare)
- Department of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden,Skane Univ Hosp, Sweden
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- Marsal, Jan (författare)
- Department of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden,Skane Univ Hosp, Sweden
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- Malmgren, Carolina (författare)
- Takeda Pharma AB, Stockholm, Sweden
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- Delin, Jenny (författare)
- Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden,Ersta Hosp, Sweden
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- Strid, Hans (författare)
- Department of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden,Sodra Alvsborgs Hosp, Sweden
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- Sjöberg, Mats (författare)
- Department of Internal Medicine, Skaraborgs Hospital, Lidköping, Sweden,Skaraborgs Hosp, Sweden
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- Bergemalm, Daniel (författare)
- Department of Gastroenterology,Orebro Univ, Sweden
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- Hjortswang, Henrik (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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(creator_code:org_t)
- Sage Publications, 2023
- 2023
- Engelska.
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Ingår i: Therapeutic Advances in Gastroenterology. - : Sage Publications. - 1756-283X .- 1756-2848. ; 16
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Real-world data on long-term outcomes of vedolizumab (VDZ) are scarce.OBJECTIVE: To assess long-term outcomes (up to 3 years) of VDZ in treating inflammatory bowel disease (IBD).DESIGN: A nationwide, prospective multicentre extension of a Swedish observational study on VDZ assessing Effectiveness And Healthcare resource utilization in patients with IBD (SVEAH).METHODS: After re-consent, data of patients with Crohn's disease (CD) (n = 68) and ulcerative colitis (UC) (n = 46) treated with VDZ were prospectively recorded using an electronic case report form integrated with the Swedish IBD Register (SWIBREG). The primary outcome was clinical remission (defined as Harvey-Bradshaw Index ⩽4 in CD and partial Mayo score ⩽2 in UC) at 104 and 156 weeks in patients with a response and/or remission 12 weeks after starting VDZ. Secondary outcomes included health-related quality of life (HRQoL) and biochemical outcomes.RESULTS: VDZ continuation rates were high at weeks 104 and 156, 88% and 84%, respectively, for CD and 87% and 78%, respectively, for UC. Of the 53 CD patients with a response/remission at 12 weeks, 40 (75%) patients were in remission at 104 weeks and 42 (79%) patients at 156 weeks. For UC, these numbers were 25/31 (81%) and 22/31 (71%), respectively. Improvements were seen in the Short Health Scale (p < 0.01 for each dimension; CD, n = 51; UC, n = 33) and the EuroQol 5-Dimensions, 5-levels index value (p < 0.01; CD, n = 39; UC, n = 30). Median plasma-C-reactive protein concentrations (mg/L) decreased from 5 at baseline to 4 in CD (p = 0.01, n = 53) and from 5 to 4 in UC (p = 0.03, n = 34) at 156 weeks. Correspondingly, median faecal-calprotectin (µg/g) decreased from 641 to 114 in CD patients (p < 0.01, n = 26) and from 387 to 37 in UC patients (p = 0.02, n = 17).CONCLUSION: VDZ demonstrated high continuation rates and was associated with improvements in clinical outcomes, HRQoL measures and inflammatory markers at 2 and 3 years after treatment initiation in this prospective national SVEAH extension study.REGISTRATION: ENCePP registration number: EUPAS22735.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Crohn’s disease
- inflammatory bowel disease
- real-world data
- ulcerative colitis
- vedolizumab
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Visuri, Isabella ...
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Eriksson, Carl, ...
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Karlqvist, Sara, ...
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Lykiardopoulos, ...
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Karlén, Per
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Grip, Olof
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Söderman, Charlo ...
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Almer, Sven
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Hertervig, Erik
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Marsal, Jan
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Malmgren, Caroli ...
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Delin, Jenny
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Strid, Hans
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Sjöberg, Mats
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Bergemalm, Danie ...
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Hjortswang, Henr ...
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Halfvarson, Jona ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Therapeutic Adva ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Linköpings universitet