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Sökning: onr:"swepub:oai:DiVA.org:oru-106370" > Elevated plasma pho...

  • Strandvik, BirgittaDepartment of Biosciences and Nutrition, Karolinska Institutet NEO, Stockholm, Sweden (författare)

Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Public Library of Science (PLoS),2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-106370
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-106370URI
  • https://doi.org/10.1371/journal.pone.0285782DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153067464URI
  • https://res.slu.se/id/publ/122482URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Westman FoundationCIMEDUniversity of Veterinary Medicine Vienna and the Austria Science Fund (FWF) P27267-B25 P31577-B25 
  • Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Qureshi, Abdul RashidDivision of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden (författare)
  • Painer, JohannaResearch Institute of Wildlife Ecology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Vienna, Austria (författare)
  • Backman-Johansson, CarolinaDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (författare)
  • Engvall, MartinDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (författare)
  • Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden; Department of Clinical Medicine, Aarhus University Health, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; StenoDiabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark(Swepub:oru)oft (författare)
  • Kindberg, JonasSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies(Swepub:slu)48411 (författare)
  • Stenvinkel, PeterDivision of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden (författare)
  • Giroud, SylvainResearch Institute of Wildlife Ecology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Vienna, Austria (författare)
  • Department of Biosciences and Nutrition, Karolinska Institutet NEO, Stockholm, SwedenDivision of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science (PLoS)18:61932-6203

Internetlänk

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  • PLOS ONE (Sök värdpublikationen i LIBRIS)

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