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Breathlessness and ...
Breathlessness and exercise performance to predict mortality in long-term oxygen therapy : The population-based DISCOVERY study
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- Björklund, Filip (författare)
- Lund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups
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- Palm, Andreas, 1971- (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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- Gorani, Jwan Abdulrazak (författare)
- Department of Medicine, Blekinge Hospital, Karlskrona, Sweden,Blekinge Hosp, Dept Med, Karlskrona, Sweden.
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- Ahmadi, Zainab (författare)
- Lund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups
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- Sundh, Josefin, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Örebro University, Faculty of Medicine and Health, Department of Respiratory Medicine, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Resp Med, Örebro, Sweden.
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- Theorell-Haglöw, Jenny (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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- Ljunggren, Mirjam (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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- Grote, Ludger, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Wadell, Karin (författare)
- Umeå University,Umeå universitet,Avdelningen för fysioterapi,Umeå Univ, Dept Community Med & Rehabil, Physiotherapy, Umeå, Sweden.
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- Ekström, Magnus (författare)
- Lund University,Lunds universitet,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Andfåddhet och kronisk andningssvikt,The Institute for Palliative Care,Lund University Research Groups,Breathlessness and chronic respiratory failure
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 216
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality.METHODS: This was a longitudinal, population-based study of patients who initiated LTOT between 2015 and 2018 in Sweden. Breathlessness was measured using the Dyspnea Exertion Scale, and exercise performance using the 30s-Sit-To-Stand test. Associations with overall and three-month mortality were analyzed using Cox-regression. Subgroup analyses were performed for patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) respectively. The predictive capacity of models was assessed using a C-statistic.RESULTS: A total of 441 patients (57.6% female, aged 75.4 ± 8.3 years) were analyzed, of whom 141 (32%) died during a median follow-up of 260 (IQR 75-460) days. Both breathlessness and exercise performance were independently associated with overall mortality in the crude models, but only exercise performance remained independently associated with overall mortality when models were adjusted for other predictors, when short-term mortality was analyzed, or when breathlessness and exercise capacity were analyzed concurrently. The multivariable model including exercise performance but not breathlessness provided a relatively high predictive capacity for overall mortality, C-statistic 0.756 (95% CI 0.702-0.810). Similar results were seen in the COPD and ILD subgroups.CONCLUSION: Exercise performance as measured by the 30s-STS may be useful to identify patients with higher mortality on LTOT for optimized management and follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Breathlessness
- Exercise performance
- Long-term oxygen therapy
- Breathlessness
- Exercise performance
- Long-term oxygen therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Björklund, Filip
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Palm, Andreas, 1 ...
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Gorani, Jwan Abd ...
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Ahmadi, Zainab
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Sundh, Josefin, ...
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Theorell-Haglöw, ...
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visa fler...
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Ljunggren, Mirja ...
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Grote, Ludger, 1 ...
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Wadell, Karin
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Ekström, Magnus
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Respiratory Medi ...
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Uppsala universitet
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Lunds universitet
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Göteborgs universitet