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  • Björklund, FilipLund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups (författare)

Breathlessness and exercise performance to predict mortality in long-term oxygen therapy : The population-based DISCOVERY study

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-106391
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-106391URI
  • https://doi.org/10.1016/j.rmed.2023.107306DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-210198URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508572URI
  • https://lup.lub.lu.se/record/2f86c36a-8b54-48fe-b7b5-98b0a1511f99URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Regional Research Council in Mid Sweden RFR-931234Agreement concerning research and education of doctors OLL-939092 ALF-979044 ALF-GBG 966 283
  • BACKGROUND: Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality.METHODS: This was a longitudinal, population-based study of patients who initiated LTOT between 2015 and 2018 in Sweden. Breathlessness was measured using the Dyspnea Exertion Scale, and exercise performance using the 30s-Sit-To-Stand test. Associations with overall and three-month mortality were analyzed using Cox-regression. Subgroup analyses were performed for patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) respectively. The predictive capacity of models was assessed using a C-statistic.RESULTS: A total of 441 patients (57.6% female, aged 75.4 ± 8.3 years) were analyzed, of whom 141 (32%) died during a median follow-up of 260 (IQR 75-460) days. Both breathlessness and exercise performance were independently associated with overall mortality in the crude models, but only exercise performance remained independently associated with overall mortality when models were adjusted for other predictors, when short-term mortality was analyzed, or when breathlessness and exercise capacity were analyzed concurrently. The multivariable model including exercise performance but not breathlessness provided a relatively high predictive capacity for overall mortality, C-statistic 0.756 (95% CI 0.702-0.810). Similar results were seen in the COPD and ILD subgroups.CONCLUSION: Exercise performance as measured by the 30s-STS may be useful to identify patients with higher mortality on LTOT for optimized management and follow-up.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Palm, Andreas,1971-Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)andpa501 (författare)
  • Gorani, Jwan AbdulrazakDepartment of Medicine, Blekinge Hospital, Karlskrona, Sweden,Blekinge Hosp, Dept Med, Karlskrona, Sweden. (författare)
  • Ahmadi, ZainabLund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups(Swepub:lu)med-zia (författare)
  • Sundh, Josefin,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Örebro University, Faculty of Medicine and Health, Department of Respiratory Medicine, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Resp Med, Örebro, Sweden.(Swepub:oru)jnsh (författare)
  • Theorell-Haglöw, JennyUppsala University,Uppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)jethe020 (författare)
  • Ljunggren, MirjamUppsala University,Uppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)mirlj221 (författare)
  • Grote, LudgerSahlgrenska University Hospital, Department of Pulmonary Medicine, Gothenburg, Sweden; Sahlgrenska Academy, Center for Sleep and Wake Disorders, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Pulm Med, Gothenburg, Sweden.;Sahlgrens Acad, Ctr Sleep & Wake Disorders, Gothenburg, Sweden. (författare)
  • Wadell, KarinUmeå University,Umeå universitet,Avdelningen för fysioterapi,Umeå Univ, Dept Community Med & Rehabil, Physiotherapy, Umeå, Sweden.(Swepub:umu)kawa0013 (författare)
  • Ekström, MagnusLund University,Lunds universitet,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Andfåddhet och kronisk andningssvikt,The Institute for Palliative Care,Lund University Research Groups,Breathlessness and chronic respiratory failure(Swepub:lu)med-mue (författare)
  • Andfåddhet och kronisk andningssviktForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Respiratory Medicine: Elsevier2160954-61111532-3064

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