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Characterization of...
Characterization of Clinically Relevant Strains of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Occurring in Environmental Sources in a Rural Area of China by Using Whole-Genome Sequencing
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- Chi, Xiaohui (författare)
- Department of Environment and Health, School of Public Health, Shandong University, Jinan, China
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- Berglund, Björn (författare)
- Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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- Zou, Huiyun (författare)
- Department of Environment and Health, School of Public Health, Shandong University, Jinan, China
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- Zheng, Beiwen (författare)
- State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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- Börjesson, Stefan, 1979- (författare)
- Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, Uppsala, Sweden
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- Ji, Xiang (författare)
- Department of Environment and Health, School of Public Health, Shandong University, Jinan, China
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- Ottoson, Jakob (författare)
- Department of Risk and Benefit Assessment, National Food Agency, Uppsala, Sweden
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- Lundborg, Cecilia Stålsby (författare)
- Karolinska Institutet
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- Li, Xuewen (författare)
- Department of Environment and Health, School of Public Health, Shandong University, Jinan, China
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- Nilsson, Lennart E (författare)
- Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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(creator_code:org_t)
- 2019-02-12
- 2019
- Engelska.
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Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 10
- Relaterad länk:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Klebsiella pneumoniae is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. The purpose of this study was to survey the occurrence of and characterize K. pneumoniae in different environmental sources in a rural area of Shandong province, China. Two hundred and thirty-one samples from different environmental sources in 12 villages were screened for extended-spectrum β-lactamase-(ESBL)-producing K. pneumoniae, and 14 (6%) samples were positive. All isolates were multidrug-resistant and a few of them belonged to clinically relevant strains which are known to cause hospital outbreaks worldwide. Serotypes, virulence genes, serum survival, and phagocytosis survival were analyzed and the results showed the presence of virulence factors associated with highly virulent clones and a high degree of phagocytosis survivability, indicating the potential virulence of these isolates. These results emphasize the need for further studies designed to elucidate the role of the environment in transmission and dissemination of ESBL-producing K. pneumoniae and the potential risk posed to human and environmental health.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Annan veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Other Veterinary Science (hsv//eng)
Nyckelord
- Klebsiella pneumoniae
- environment
- extended-spectrum β-lactamase
- feces
- multilocus sequence typing
- pulsed-field gel electrophoresis
- water
- whole-genome sequencing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Chi, Xiaohui
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Berglund, Björn
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Zou, Huiyun
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Zheng, Beiwen
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Börjesson, Stefa ...
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Ji, Xiang
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visa fler...
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Ottoson, Jakob
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Lundborg, Cecili ...
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Li, Xuewen
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Nilsson, Lennart ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Veterinärmedicin
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och Annan veterinärm ...
- Artiklar i publikationen
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Frontiers in Mic ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet