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Defining Comprehens...
Defining Comprehensive Disease Control for use as a Treatment Target for Ulcerative Colitis in Clinical Practice : International Delphi Consensus Recommendations
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- Schreiber, Stefan (författare)
- University Hospital Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany
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- Danese, Silvio (författare)
- IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy
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- Dignass, Axel (författare)
- Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt, Germany
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- Domènech, Eugeni (författare)
- Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol and CIBEREHD, Badalona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
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- Fantini, Massimo C. (författare)
- Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy
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- Ferrante, Marc (författare)
- Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Hart, Ailsa (författare)
- St. Mark's Hospital, Greater London, UK
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- Magro, Fernando (författare)
- CINTESIS@RISE, Faculty of Medicine of the University of Porto, Porto, Portugal
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- Lees, Charlie W. (författare)
- Edinburgh Inflammatory Bowel Disease Unit, Western General Hospital, Edinburgh, UK
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- Leone, Salvo (författare)
- European Federation of Crohn's & Ulcerative Colitis Associations (EFCCA), Brussels, Belgium
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- Pierik, Marieke J. (författare)
- Division Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, Netherlands
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- Peters, Michele (författare)
- Nuffield Department of Population Health, University of Oxford, Oxford, UK
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- Field, Polly (författare)
- Oxford PharmaGenesis, Oxford, UK
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- Fishpool, Helen (författare)
- Oxford PharmaGenesis, Oxford, UK
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- Peyrin-Biroulet, Laurent (författare)
- Department of Gastroenterology, Nancy University Hospital, Vandœuvre-lès-Nancy,France; Inserm, NGERE, University of Lorraine, Nancy, France; INFINY Institute, Nancy University Hospital, Vandœuvre-lès-Nancy, France; FHU-CURE, Nancy University Hospital, Vandœuvre-lès-Nancy, France; Groupe Hospitalier privé Ambroise Paré - Hartmann, Paris IBD Center, Neuilly sur Seine, France; Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada
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(creator_code:org_t)
- Oxford University Press, 2024
- 2024
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 18:1, s. 91-105
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND AND AIMS: Treatment of ulcerative colitis (UC) requires a patient-centric, definition of comprehensive disease control that considers improvements in aspects not typically captured by classical landmark trial endpoints. In an international initiative we reviewed aspects of UC that affect patients and/or indicate mucosal inflammation, to achieve consensus on which aspects to combine in a definition of comprehensive disease control, using a modified Delphi process.METHODS: The Delphi panel comprised 12 gastroenterologists and one patient advocate. Two gastroenterologists were elected as chairs and did not vote. To inform statements, we asked 18 patients and the panel members about their experiences of remission and reviewed published literature. Panel members voted on statements anonymously in three rounds, with a live discussion before round 3. Consensus was met if ≥ 67% of the panel agreed. Statements without consensus in rounds 1 and 2 were revised or discarded after round 3.RESULTS: The panel agreed to measure individual patient benefit using a definition of comprehensive disease control that combines aspects currently measured in trials (rectal bleeding, stool frequency, disease-related quality of life, endoscopy, histological inflammatory activity, inflammatory biomarkers, and corticosteroid use), with additional patient-reported symptoms (bowel urgency, abdominal pain, extraintestinal manifestations, fatigue, and sleep disturbance). The panel agreed on scoring systems and thresholds for many aspects.CONCLUSIONS: Using a robust methodology, we defined comprehensive disease control in UC. Next, we will combine the measurement and scoring of these aspects into a multi-component tool and adopt comprehensive disease control as a treatment target in clinical practice and trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Delphi consensus
- Ulcerative colitis
- patient-reported symptoms
- remission
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- ref (ämneskategori)
- art (ämneskategori)
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Schreiber, Stefa ...
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Danese, Silvio
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Dignass, Axel
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Domènech, Eugeni
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Fantini, Massimo ...
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Ferrante, Marc
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Halfvarson, Jona ...
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Hart, Ailsa
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Magro, Fernando
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Lees, Charlie W.
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Leone, Salvo
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Pierik, Marieke ...
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Peters, Michele
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Field, Polly
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Fishpool, Helen
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Peyrin-Biroulet, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Journal of Crohn ...
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Örebro universitet