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Self-Reporting Ther...
Self-Reporting Theranostic : Nano Tool for Arterial Thrombosis
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- Deb, Suryyani (författare)
- Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, India,Maulana Abul Kalam Azad Univ Technol, India
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- Azharuddin, Mohammad (författare)
- Cambridge Display Technology Ltd., Huntingdon PE29 2XG, UK,Cambridge Display Technol Ltd, England
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- Ramström, Sofia, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
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- Ghosh, Kanjaksha (författare)
- National Institute of Immunohaematology, KEM Hospital Campus, Mumbai 400012, India,KEM Hosp Campus, India
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- Singha, Santiswarup (författare)
- National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India,Natl Inst Immunol, India
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- Romu, Thobias (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Patra, Hirak Kumar (författare)
- Department of Surgical Biotechnology, UCL Division of Surgery and Interventional Sciences, University College London, London NW3 2PF, UK,UCL, England
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(creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: Bioengineering. - : MDPI. - 2306-5354. ; 10:9
- Relaterad länk:
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Arterial thrombosis (AT) originates through platelet-mediated thrombus formation in the blood vessel and can lead to heart attack, stroke, and peripheral vascular diseases. Restricting the thrombus growth and its simultaneous monitoring by visualisation is an unmet clinical need for a better AT prognosis. As a proof-of-concept, we have engineered a nanoparticle-based theranostic (combined therapy and monitoring) platform that has the potential to monitor and restrain the growth of a thrombus concurrently. The theranostic nanotool is fabricated using biocompatible super-paramagnetic iron oxide nanoparticles (SPIONs) as a core module tethered with the anti-platelet agent Abciximab (ReoPro) on its surface. Our in vitro feasibility results indicate that ReoPro-conjugated SPIONS (Tx@ReoPro) can effectively prevent thrombus growth by inhibiting fibrinogen receptors (GPIIbIIIa) on the platelet surface, and simultaneously, it can also be visible through non-invasive magnetic resonance imaging (MRI) for potential reporting of the real-time thrombus status.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- MRI
- ReoPro
- arterial thrombosis
- platelet aggregations
- theranostics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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