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Ototoxicity associa...
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Lange, Anna,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases
(författare)
Ototoxicity associated with extended dalbavancin treatment for a shoulder prosthetic joint infection
- Artikel/kapitelEngelska2023
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BioMed Central (BMC),2023
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LIBRIS-ID:oai:DiVA.org:oru-109339
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109339URI
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https://doi.org/10.1186/s12879-023-08709-8DOI
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Språk:engelska
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Sammanfattning på:engelska
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BACKGROUND: Dalbavancin is a lipoglycopeptide antibiotic approved for treatment of skin and soft tissue infections, administered as a single or two-dose treatment. The extended half-life, good penetration into bone and synovial fluid, and bactericidal activity against gram-positive bacteria, including those in biofilm, make dalbavancin an appealing choice for treatment of bone and joint infections in outpatient settings. However, we present a rare case of ototoxicity associated with off-label extended dalbavancin treatment of a prosthetic joint infection.CASE PRESENTATION: A 55-year-old man with a prosthetic joint infection of the shoulder underwent off-label extended dalbavancin treatment, receiving a cumulative dose of 2500 mg. The patient experienced a gradual onset of hearing loss following the first dose, leading to a diagnosis of bilateral sensorineural hearing loss that persisted 1 year after dalbavancin was discontinued.CONCLUSIONS: This case report highlights the importance of exercising caution when administering dalbavancin beyond approved dosing guidelines, and emphasizes the need for vigilance regarding the potential for ototoxicity.
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Thunberg, Ulrica,1967-Örebro universitet,Institutionen för hälsovetenskaper,Institutionen för medicinska vetenskaper,Department of Otorhinolaryngology(Swepub:oru)uatg
(författare)
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Söderquist, Bo,1955-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)bost
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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Ingår i:BMC Infectious Diseases: BioMed Central (BMC)23:11471-2334
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