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Altered biomarkers ...
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
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- Saevik, Ase Bjorvatn (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway,Univ Bergen, Norway; Univ Bergen, Norway
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- Ueland, Grethe (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway
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- Akerman, Anna-Karin (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden
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- Methlie, Paal (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway
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- Quinkler, Marcus (författare)
- Practice for Endocrinology and Nephrology, Endocrinology in Charlottenburg, Berlin, Germany,Endocrinol Charlottenburg, Germany
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- Jorgensen, Anders Palmstrom (författare)
- Department of Endocrinology, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
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- Hoybye, Charlotte (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Wahlberg, Jeanette (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
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- Nedrebo, Bjorn Gunnar (författare)
- Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway
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- Dahle, Anne Lise (författare)
- Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway
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- Carlsen, Siri (författare)
- Department of Endocrinology, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Norway
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- Tomkowicz, Aneta (författare)
- Department of Medicine, Sørlandet Hospital, Kristiansand, Norway,Sorlandet Hosp, Norway
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- Sollid, Stina Therese (författare)
- Department of Medicine, Drammen Hospital, Vestre Viken Health Trust, Drammen, Norway,Drammen Hosp, Norway
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- Nermoen, Ingrid (författare)
- Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
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- Gronning, Kaja (författare)
- Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
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- Dahlqvist, Per (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden
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- Grimnes, Guri (författare)
- Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway,Univ Hosp North Norway, Norway; UiT Arctic Univ Norway, Norway
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- Skov, Jakob (författare)
- Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Finnes, Trine (författare)
- Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway
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- Valland, Susanna F. (författare)
- Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway
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- Wahlberg, Jeanette, 1969- (författare)
- Linköping University, Linköping, Sweden
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- Holte, Synnove Emblem (författare)
- Department of Medicine, Sørlandet Hospital, Arendal, Norway,Sorlandet Hosp, Norway
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- Kampe, Olle (författare)
- Karolinska Institutet,Univ Bergen, Norway; Karolinska Inst, Sweden
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- Bensing, Sophie (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Husebye, Eystein Sverre (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden
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- Oksnes, Marianne (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden
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Department of Clinical Science, University of Bergen, Bergen, Norway; KG. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway Univ Bergen, Norway; Univ Bergen, Norway (creator_code:org_t)
- Bioscientifica, 2023
- 2023
- Engelska.
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Ingår i: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 189:4, s. 438-447
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addisons disease (AAD), but pathomechanisms are poorly understood.Design: Cross-sectional study.Methods: We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at >18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified for sex. Biomarker levels were correlated with the frequency of adrenal crises and quality of life (QoL) by AddiQoL-30. Finally, we investigated changes in biomarker levels following 250 mu g tetracosactide injection in patients without residual adrenocortical function (RAF) to explore glucocorticoid-independent effects of high ACTH.Results: Nineteen biomarkers significantly differed between patients with AAD and controls; all but 1 (ST1A1) were higher in AAD. Eight biomarkers were significantly higher in female patients compared with controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, and PGF), but none differed between male patients and controls. Levels of RAGE correlated with the frequency of adrenal crises (r = 0.415, P = .006) and AddiQoL-30 scores (r = -0.347, P = .028) but not after correction for multiple testing. PDL2 and leptin significantly declined 60 min after injection of ACTH in AAD without RAF (-0.15 normalized protein expression [NPX], P = .0001, and -0.25 NPX, P = .0003, respectively).Conclusions: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Autoimmunity
- primary adrenal insufficiency
- cardiovascular disease
- proteomics
- biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Saevik, Ase Bjor ...
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Ueland, Grethe
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Akerman, Anna-Ka ...
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Methlie, Paal
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Quinkler, Marcus
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Jorgensen, Ander ...
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visa fler...
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Hoybye, Charlott ...
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Wahlberg, Jeanet ...
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Nedrebo, Bjorn G ...
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Dahle, Anne Lise
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Carlsen, Siri
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Tomkowicz, Aneta
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Sollid, Stina Th ...
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Nermoen, Ingrid
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Gronning, Kaja
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Dahlqvist, Per
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Grimnes, Guri
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Skov, Jakob
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Finnes, Trine
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Valland, Susanna ...
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Wahlberg, Jeanet ...
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Holte, Synnove E ...
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Kampe, Olle
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Bensing, Sophie
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Husebye, Eystein ...
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Oksnes, Marianne
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Karolinska Institutet
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Linköpings universitet