Sökning: onr:"swepub:oai:DiVA.org:oru-110375" >
Mild traumatic brai...
Mild traumatic brain injury-induced persistent blood-brain barrier disruption is prevented by cyclosporine A treatment in hypertension
-
- Lendvai-Emmert, Dominika (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary
-
- Magyar-Sumegi, Zsofia Dina (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary
-
- Hegedus, Emoke (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pecs, Pecs, Hungary
-
visa fler...
-
- Szarka, Nikolett (författare)
- Department of Primary Health Care, Medical School, University of Pecs, Pecs, Hungary
-
- Fazekas, Balint (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary
-
- Amrein, Krisztina (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary; ELKH-PTE Clinical Neuroscience MR Research Group, University of Pecs, Pecs, Hungary
-
- Czeiter, Endre (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary; ELKH-PTE Clinical Neuroscience MR Research Group, University of Pecs, Pecs, Hungary
-
- Büki, Andras, 1966- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Department of Neurosurgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Ungvari, Zoltan (författare)
- Department of Neurosurgery, Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Department of Public Health, International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Semmelweis University, Budapest, Hungary
-
- Toth, Peter (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary; ELKH-PTE Clinical Neuroscience MR Research Group, University of Pecs, Pecs, Hungary; Department of Neurosurgery, Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Department of Public Health, International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Semmelweis University, Budapest, Hungary
-
visa färre...
-
(creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- Engelska.
-
Ingår i: Frontiers in Neurology. - : Frontiers Media S.A.. - 1664-2295. ; 14
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- INTRODUCTION: Mild traumatic brain injury (mTBI) and hypertension synergize to induce persistent disruption of the blood-brain barrier (BBB), neuroinflammation and cognitive decline. However, the underlying mechanisms are not known. Cerebral production of Cyclophilin A (CyPA) is induced in hypertension and after TBI, and it was demonstrated to activate the nuclear factor-κB (NF-kB)- matrix-metalloproteinase-9 (MMP-9) pathway in cerebral vessels leading to BBB disruption.METHODS: To test the role of CyPA in mTBI- and hypertension-induced BBB disruption we induced mTBI in normotensive and spontaneously hypertensive rats (SHR), then the animals were treated with cyclosporine A (a specific inhibitor of CyPA production) or vehicle for 7 days. We assessed BBB permeability and integrity, cerebral expression and activity of the CyPA-NF-kB-MMP-9 pathway, extravasation of fibrin and neuroinflammation.RESULTS: We found that mild TBI induced BBB disruption and upregulation of the CyPA-NF-kB-MMP-9 pathway in hypertension, which were prevented by blocking CyPA. Cyclosporine treatment and preservation of BBB function prevented accumulation of blood-derived fibrin in the brain parenchyma of hypertensive rats after mTBI and reversed increased neuroinflammation.DISCUSSION: We propose that mTBI and hypertension interact to promote BBB disruption via the CyPA-NF-kB-MMP-9 pathway, and inhibition of cyclophilin production after mTBI may exert neuroprotection and improve cognitive function in hypertensive patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- BBB
- CyPA
- hypertension
- mTBI
- neuroinflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lendvai-Emmert, ...
-
Magyar-Sumegi, Z ...
-
Hegedus, Emoke
-
Szarka, Nikolett
-
Fazekas, Balint
-
Amrein, Krisztin ...
-
visa fler...
-
Czeiter, Endre
-
Büki, Andras, 19 ...
-
Ungvari, Zoltan
-
Toth, Peter
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Frontiers in Neu ...
- Av lärosätet
-
Örebro universitet