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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005334naa a2200505 4500
001oai:DiVA.org:oru-111022
003SwePub
008240130s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:238233033
009oai:lup.lub.lu.se:5bedb531-2142-4f7f-9957-9b6d8d35bf3d
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1110222 URI
0247 a https://doi.org/10.1136/bmj-2023-0775642 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2382330332 URI
0247 a https://lup.lub.lu.se/record/5bedb531-2142-4f7f-9957-9b6d8d35bf3d2 URI
040 a (SwePub)orud (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fernández de la Cruz, Lorenau Karolinska Institute,Karolinska Institutet4 aut
2451 0a All cause and cause specific mortality in obsessive-compulsive disorder :b nationwide matched cohort and sibling cohort study
264 1b BMJ Publishing Group Ltd,c 2024
338 a print2 rdacarrier
520 a OBJECTIVE: To estimate the risk of all cause and cause specific mortality in people with obsessive-compulsive disorder (OCD) compared with matched unaffected people from the general population and with their unaffected siblings. DESIGN: Population based matched cohort and sibling cohort study. SETTING: Register linkage in Sweden.PARTICIPANTS: Population based cohort including 61 378 people with OCD and 613 780 unaffected people matched (1:10) on sex, birth year, and county of residence; sibling cohort consisting of 34 085 people with OCD and 47 874 unaffected full siblings. Cohorts were followed up for a median time of 8.1 years during the period from 1 January 1973 to 31 December 2020. MAIN OUTCOME MEASURES: All cause and cause specific mortality.RESULTS: 4787 people with OCD and 30 619 unaffected people died during the study period (crude mortality rate 8.1 and 5.1 per 1000 person years, respectively). In stratified Cox proportional hazards models adjusted for birth year, sex, county, migrant status (born in Sweden versus abroad), and sociodemographic variables (latest recorded education, civil status, and family income), people with OCD had an increased risk of all cause mortality (hazard ratio 1.82, 95% confidence interval 1.76 to 1.89) and mortality due to natural causes (1.31, 1.27 to 1.37) and unnatural causes (3.30, 3.05 to 3.57). Among the natural causes of death, those due to endocrine, nutritional, and metabolic diseases, mental and behavioural disorders, and diseases of the nervous, circulatory, respiratory, digestive, and genitourinary systems were higher in the OCD cohort. Conversely, the risk of death due to neoplasms was lower in the OCD cohort compared with the unaffected cohort. Among the unnatural causes, suicide showed the highest hazard ratio, followed by accidents. The results were robust to adjustment for psychiatric comorbidities and familial confounding.CONCLUSIONS: Non-communicable diseases and external causes of death, including suicides and accidents, were major contributors to the risk of mortality in people with OCD. Better surveillance, prevention, and early intervention strategies should be implemented to reduce the risk of fatal outcomes in people with OCD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
7001 a Isomura, Kayokou Karolinska Institute4 aut
7001 a Lichtenstein, Paulu Karolinska Institute4 aut
7001 a Larsson, Henrik,d 1975-u Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)hiln
7001 a Kuja-Halkola, Ralfu Karolinska Institute,Karolinska Institutet4 aut
7001 a Chang, Zhengu Karolinska Institute,Karolinska Institutet4 aut
7001 a D'Onofrio, Brian M.u Karolinska Institute,Indiana University4 aut
7001 a Brikell, Isabellu Karolinska Institute,Aarhus University,University of Bergen4 aut
7001 a Rück, Christianu Karolinska Institute,Karolinska Institutet4 aut
7001 a Sidorchuk, Annau Karolinska Institute,Karolinska Institutet4 aut
7001 a Mataix-Cols, Davidu Karolinska Institute,Lund University,Lunds universitet,Innovations in pediatric mental health,Forskargrupper vid Lunds universitet,Lund University Research Groups,Stockholm Regional Council4 aut0 (Swepub:lu)da5182ma
7102 a Karolinska Instituteb Karolinska Institutet4 org
7730 t BMJ (Clinical Research Edition)d : BMJ Publishing Group Ltdg 384q 384x 0959-8138x 1756-1833
7730 t BMJd : BMJ Publishing Group Ltdg 384q 384x 0959-8146
8564 u https://doi.org/10.1136/bmj-2023-077564y Fulltext
8564 u http://dx.doi.org/10.1136/bmj-2023-077564x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111022
8564 8u https://doi.org/10.1136/bmj-2023-077564
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:238233033
8564 8u https://lup.lub.lu.se/record/5bedb531-2142-4f7f-9957-9b6d8d35bf3d

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