Long-Term Effect of Maintenance Electroconvulsive Therapy in Patients With Depression-Data From a Small Randomized Controlled Trial

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Brus, Ole,1982-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical epidemiology and biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)

Long-Term Effect of Maintenance Electroconvulsive Therapy in Patients With Depression-Data From a Small Randomized Controlled Trial

Artikel/kapitelEngelska2024

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2024
Lippincott Williams & Wilkins,2024
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LIBRIS-ID:oai:DiVA.org:oru-111028
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111028URI
https://doi.org/10.1097/YCT.0000000000000983DOI

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Språk:engelska
Sammanfattning på:engelska

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Uppsala-Örebro Regional Research Council and Research Committee of Örebro County Council, Örebro, Sweden, supported the research
OBJECTIVES: This study aimed to compare the long-term effects of maintenance electroconvulsive therapy (M-ECT) with medication and medication only in patients with depression.METHODS: A randomized controlled trial of 1 year of M-ECT with medication or medication only investigated relapse/recurrence among 56 patients in remission after electroconvulsive therapy (ECT) for depression was conducted. The results of the first year are published already and showed a significant advantage of M-ECT with medication.The current study was a long-term follow-up. When the randomized treatment allocation ended, medication was continued in both groups but M-ECT was terminated. Patients were followed for up to 10 years via Swedish national registers until the study endpoint of a new psychiatric diagnosis as an inpatient, suicide, suspected suicide, or death of another cause. Time to relapse was compared between the M-ECT with medication group and the medication-only group using Kaplan-Meier estimates.RESULTS: The median follow-up time was 6.5 years for the M-ECT and medication group and 3.1 years for the medication-only group. One year after randomization 22 patients remained in the M-ECT and medication group, and 14 patients remained in the medication-only group. Relapse patterns between the treatment groups after the completion of M-ECT seemed to be similar according to visual inspection.CONCLUSIONS: This long-term follow-up study suggests that most of the benefit achieved during the treatment period with M-ECT is maintained over several years, but the small sample size, with accompanying large statistical imprecision, makes the results uncertain. More long-term studies of M-ECT are required.Trial registration: ClinicalTrials.gov identifier: NCT00627887.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Cao, Yang,Associate Professor,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical epidemiology and biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)yco (författare)
Carlborg, AndreasDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (författare)
Engström, Ingemar,1952-Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)iem (författare)
von Knorring, LarsDepartment of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden (författare)
Nordenskjöld, Axel,1977-Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)alnd (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of ECT: Lippincott Williams & Wilkins1095-06801533-4112

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Av författaren/redakt...: Brus, Ole, 1982-; Cao, Yang, Assoc ...; Carlborg, Andrea ...; Engström, Ingema ...; von Knorring, La ...; Nordenskjöld, Ax ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: Journal of ECT

Av lärosätet: Örebro universitet

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