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Transcriptional pro...
Transcriptional profiling of stress response in cultured porcine islets
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- Dvorak, C.M.T. (författare)
- University of Minnesota, Minnesota, USA
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- Hårdstedt, Maria, 1971- (författare)
- Diabetes Institute of Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, USA
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- Xie, H. (författare)
- University of Minnesota, Minnesota, USA
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- Wang, M. (författare)
- University of Minnesota, Minnesota, USA
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- Papas, K.K. (författare)
- University of Minnesota, Minnesota, USA
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- Hering, Bernhard J. (författare)
- University of Minnesota, Minnesota, USA
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- Murtaugh, M.P. (författare)
- University of Minnesota, Minnesota, USA
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- Fahrenkrug, S.C. (författare)
- University of Minnesota, Minnesota, USA
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(creator_code:org_t)
- Academic Press, 2007
- 2007
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Academic Press. - 0006-291X .- 1090-2104. ; 357:1, s. 118-125
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cell-based diabetes therapy may be achieved through xenotransplantation of adult porcine islets, but tissue quality and immunoreactivity barriers need to be overcome. Early identification and exclusion of irreversibly stressed and dying islets may improve transplant outcomes. We used oligonucleotide microarray and quantitative RT-PCR to identify molecular markers of physiological and immunological stress in porcine islets cultured under stress conditions of elevated glucose (16.7 mM), inflammatory cytokine addition (IL-1beta, TNF-alpha, and IFN-gamma), or both, for 48 h. Hyperglycemic conditions were associated with increased thioredoxin interacting protein and metabolic process mRNAs, as observed in rodent and primate species. Cytokine treatment increased expression of JAK-STAT pathway components, oxidative stress (transglutaminase 2), and beta cell dysfunction genes. Transglutaminase 2 induction is unique to porcine islets. Biomarkers involved in hyperglycemia and islet inflammation may serve as novel targets for improving and monitoring isolated porcine islet function and viability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Diabetes
- islet cells
- microarray
- gene expression
- swine
- cytokines
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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