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Real-World Outcomes...
Real-World Outcomes of Patients Starting Intravenous and Transitioning to Subcutaneous Vedolizumab in Inflammatory Bowel Disease
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- Lamichhane, N. (författare)
- Örebro University
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- Melas, N. (författare)
- Örebro University,Karlstad Hospital
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- Bergqvist, V. (författare)
- Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Ekholm, N-P. (författare)
- Takeda Pharma, Medical Affairs, Stockholm, Sweden
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- Olén, O. (författare)
- Karolinska Institute,Karolinska Institutet,Stockholm South General Hospital
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institute,Karolinska Institutet,Region Örebro län,Department of Paediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Orebro Univ Hosp, Sweden; Columbia Univ, NY USA; Karolinska Inst, Sweden
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- Hjortswang, Henrik (författare)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Marsal, J. (författare)
- Lund University,Lunds universitet,Gastro,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Eriksson, Carl, 1981- (författare)
- Örebro University,Karolinska Institute,Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Karolinska Inst, Sweden; Orebro Univ, Sweden
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- Halfvarson, Jonas, 1970- (författare)
- Örebro University
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SWIBREG, - (bidragsgivare)
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(creator_code:org_t)
- Kluwer Academic Publishers, 2024
- 2024
- Engelska.
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Ingår i: Digestive Diseases and Sciences. - : Kluwer Academic Publishers. - 0163-2116 .- 1573-2568. ; 69:6, s. 2175-2183
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Real-world data on starting intravenous (IV) vedolizumab (VDZ) and transitioning to subcutaneous (SC) treatment in inflammatory bowel disease (IBD) are scarce. AIMS: To assess treatment outcomes of patients with IBD starting IV VDZ and switching to SC VDZ in routine clinical care.METHODS: Adult patients with IBD switching from IV to SC VDZ treatment between 1 March 2020 and 31 December 2021 were identified from the Swedish IBD quality register. The primary outcome was SC VDZ persistence. Secondary outcomes included clinical remission, changes in quality of life (QoL) according to EuroQual 5-Dimensions 5-Levels (EQ-5D-5L) and the Short-Health Scale (SHS) and inflammatory markers, including faecal Calprotectin (FCP).RESULTS: Altogether, 406 patients with IBD (Crohn's disease, n = 181; ulcerative colitis, n = 225) were identified. After a median follow-up of 30 months from starting IV VDZ treatment, the persistence rates were 98%(178/181) in Crohn's disease and 94% (211/225) in ulcerative colitis. Most patients (84%) transitioned during maintenance therapy, and the median follow-up from switch to SC VDZ was 10 months. Compared to baseline, statistically significant improvements were observed in all domains of the SHS, EQ-5D index value and visual analogue scale. Median (interquartile range) FCP concentrations (μg/g) decreased from 459 (185-1001) to 65 (26-227) in Crohn's disease (n = 45; p < 0.001) and from 646 (152-1450) to 49 (20-275) in ulcerative colitis (n = 58; p < 0.001).CONCLUSION: Initiating IV VDZ and switching to SC treatment was associated with high persistence rates and improvements in measures of QoL and FCP. These findings are reassuring for patients who start IV VDZ and switch to SC VDZ.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Inflammatory bowel disease
- Observational study
- Real-world data
- Vedolizumab
- Inflammatory bowel disease
- Observational study
- Real-world data
- Vedolizumab
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Lamichhane, N.
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Melas, N.
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Bergqvist, V.
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Ekholm, N-P.
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Olén, O.
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Ludvigsson, Jona ...
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Hjortswang, Henr ...
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Marsal, J.
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Eriksson, Carl, ...
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Halfvarson, Jona ...
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SWIBREG, -
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Digestive Diseas ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet
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Karolinska Institutet
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Lunds universitet