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Cyclosporin A limit...
Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury
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- Okonkwo, David O. (författare)
- Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
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- Büki, Andras, 1966- (författare)
- Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, United States; Department of Neurosurgery, University Medical School of Pécs, Hungary
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- Siman, Robert (författare)
- Cephalon, West Chester, PA 19380, USA
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- Povlishock, John T. (författare)
- Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 1999
- 1999
- Engelska.
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Ingår i: NeuroReport. - : Lippincott Williams & Wilkins. - 0959-4965 .- 1473-558X. ; 10:2, s. 353-358
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In traumatic axonal injury, Ca2+ influx across a focally damaged axolemma precipitates local mitochondrial failure, degradation of the subaxolemmal spectrin network and compaction of neurofilaments, which collectively contribute to axonal failure. In previous studies, cyclosporin A pretreatment preserved mitochondrial integrity and attenuated axonal failure following trauma. Here we investigate whether this CsA-linked protection was related to the concomitant blunting of intra-axonal, Ca2+-induced cytoskeletal changes in traumatic axonal injury, assessed with antibodies targeting spectrin proteolysis and neurofilament compaction. CsA pretreatment dramatically reduced Ca2+-induced cytoskeletal damage following injury; CsA-treated rats, compared with vehicle-treated rats, displayed a 70% decrease in immunoreactive/damaged profiles. We suggest that CsA-mediated preservation of mitochondrial integrity enables the restoration of ionic and metabolic homeostasis thereby short-circuiting Ca2+-induced proteolysis in injured axons.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (ämneskategori)
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