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Increased level of ...
Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage
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- Schranz, Daniel (författare)
- Department of Neurology, University of Pecs, Medical School, Pecs, Hungary
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- Molnar, Tihamer (författare)
- Department of Anaesthesiology and Intensive Care, University of Pecs, Medical School, Pecs, Hungary
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- Erdo‐Bonyar, Szabina (författare)
- Department of Immunology and Biotechnology, University of Pecs, Medical School, Pecs, Hungary
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- Simon, Diana (författare)
- Department of Immunology and Biotechnology, University of Pecs, Medical School, Pecs, Hungary
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- Berki, Tímea (författare)
- Department of Immunology and Biotechnology, University of Pecs, Medical School, Pecs, Hungary
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- Nagy, Csaba (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary
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- Czeiter, Endre (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; MTA‐PTE Clinical Neuroscience, MR Research Group, Pécs, Hungary
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary
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- Lenzser, Gabor (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary
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- Csecsei, Peter (författare)
- Department of Neurosurgery, University of Pecs, Medical School, Pecs, Hungary
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(creator_code:org_t)
- 2021-01-25
- 2021
- Engelska.
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Ingår i: Acta Neurologica Scandinavica. - : John Wiley & Sons. - 0001-6314 .- 1600-0404. ; 143:5, s. 530-537
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Multiple cytokines have been implicated in aneurysmal subarachnoid hemorrhage (aSAH), but tumor necrosis factor superfamily 14 (LIGHT/TNFSF14) and oncostatin-M (OSM) have not been previously explored.Aims of the study: The primary objective of this study was to examine the relationship between TNFSF14 and OSM levels and survival. Our secondary goal was to investigate a potential association between these markers and the incidence of delayed cerebral ischemia (DCI).Materials & methods: We consecutively recruited 60 patients with a clinical diagnosis of aSAH. LIGHT/TNFSF14 and OSM serum concentrations were determined by ELISA. The primary endpoint was survival at Day 30, while development of DCI was assessed as secondary outcome.Results: Patients had significantly higher levels of both markers than the control group (median of LIGHT: 18.1 pg/ml vs. 7 pg/ml; p = 0.01; median of OSM: 10.3 pg/ml vs. 2.8 pg/ml, p < 0.001). Significantly lower serum level of LIGHT/TNFSF14 was found in nonsurviving patients (n = 9) compared with survivors (n = 51; p = 0.011). Based on ROC analysis, serum LIGHT/TNFSF14 with a cutoff value of >7.95 pg/ml predicted 30-day survival with a sensitivity of 71% and specificity of 78% (Area: 0.763; 95% CI: 0.604-0.921, p = 0.013). In addition, it was also a predictor of DCI with a sensitivity of 72.7% and a specificity of 62.5% (AUC: 0.702; 95% CI: 0.555-0.849, p = 0.018). Based on binary logistic regression analysis, LIGHT/TNFSF14 was found to be independently associated with 30-day mortality, but not with DCI.Conclusion: In this cohort, a higher serum level of LIGHT/TNFSF14 was associated with increased survival of patients with aSAH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- LIGHT
- TNFSF14
- mortality
- subarachnoid hemorrhage
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schranz, Daniel
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Molnar, Tihamer
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Erdo‐Bonyar, Sza ...
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Simon, Diana
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Berki, Tímea
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Nagy, Csaba
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Czeiter, Endre
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Büki, Andras, 19 ...
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Lenzser, Gabor
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Csecsei, Peter
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Acta Neurologica ...
- Av lärosätet
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Örebro universitet