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  • Salihovic, Samira,Associate Senior Lecturer,1985-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden. (författare)

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-114075
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114075URI
  • https://doi.org/10.1038/s41467-024-48763-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205164URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533103URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:158468709URI
  • https://gup.ub.gu.se/publication/339486URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This work was supported by the Swedish Foundation for Strategic Research [RB13-0160 to J.H.], the Swedish Research Council [2020-02021 to J.H.], the Örebro University Hospital research foundation [OLL-890291 to J.H.], NordForsk [90569 to J.H.]. 
  • Funding Agencies|Swedish Foundation for Strategic Research [RB13-0160]; Swedish Research Council [2020-02021]; Orebro University Hospital research foundation [OLL-890291]; NordForsk [90569]
  • Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nyström, NiklasUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)nikny423 (författare)
  • Mathisen, Charlotte Bache-WiigDepartment of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway. (författare)
  • Kruse, Robert,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Clin Res Lab, Örebro, Sweden.(Swepub:oru)rke (författare)
  • Olbjørn, ChristineDepartment of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Dept Pediat & Adolescent Med, Lorenskog, Norway. (författare)
  • Andersen, SvendDepartment of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway,Vestfold Hosp Trust, Dept Pediat, Tonsberg, Norway. (författare)
  • Noble, Alexandra J.Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England. (författare)
  • Dorn-Rasmussen, MariaDepartment of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark. (författare)
  • Bazov, Igor,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.(Swepub:oru)ibv (författare)
  • Perminow, GøriDepartment of Pediatric Medicine, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Pediat Med, Oslo, Norway. (författare)
  • Opheim, RandiDepartment of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway. (författare)
  • Detlie, Trond EspenDepartment of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Dept Gastroenterol, Lorenskog, Norway.;Univ Oslo, Fac Med, Oslo, Norway. (författare)
  • Huppertz-Hauss, GertDepartment of Gastroenterology, Telemark Hospital Trust, Skien, Norway,Telemark Hosp Trust, Dept Gastroenterol, Skien, Norway. (författare)
  • Hedin, Charlotte R. H.Karolinska Institutet (författare)
  • Carlson, Marie,1957-Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)maricarl (författare)
  • Öhman, Lena,1967Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xohmal (författare)
  • Magnusson, Maria K,1972Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xmmara (författare)
  • Keita, ÅsaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.(Swepub:liu)asave24 (författare)
  • Söderholm, Johan DLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.(Swepub:liu)sodda63 (författare)
  • D'Amato, MauroIKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy,Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.;CIC bioGUNE BRTA, Gastrointestinal Genet Lab, Derio, Spain.;LUM Univ, Dept Med & Surg, Casamassima, Italy. (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Univ Turku, Turku Biosci Ctr, Turku, Finland.;Abo Akad Univ, Turku, Finland.(Swepub:oru)moc (författare)
  • Wewer, VibekeDepartment of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark. (författare)
  • Satsangi, JackTranslational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England. (författare)
  • Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.(Swepub:oru)melt (författare)
  • Burisch, JohanCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Med Div, Gastrounit, Hvidovre, Denmark. (författare)
  • Uhlig, Holm H.Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.;Univ Oxford, Dept Paediat, Oxford, England. (författare)
  • Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.(Swepub:oru)drr (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro Univ, Sch Sci & Technol, Örebro, Sweden.(Swepub:oru)tihn (författare)
  • Høivik, Marte LieDepartment of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway. (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.(Swepub:oru)jshn (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Communications: Springer Nature15:12041-1723

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