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New definition for ...
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Mortensen, Henrik B.
(författare)
New definition for the partial remission period in children and adolescents with type 1 diabetes
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-05-12
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American Diabetes Association,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-12086
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12086URI
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https://doi.org/10.2337/dc08-1987DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE To find a simple definition of partial remission in type 1 diabetes that reflects both residual beta-cell function and efficacy of insulin treatment. RESEARCH DESIGN AND METHODS A total of 275 patients aged <16 years were followed from onset of type 1 diabetes. After 1, 6, and 12 months, stimulated C-peptide during a challenge was used as a measure of residual beta-cell function. RESULTS By multiple regression analysis, a negative association between stimulated C-peptide and A1C (regression coefficient -0.21, P < 0.001) and insulin dose (-0.94, P < 0.001) was shown. These results suggested the definition of an insulin dose-adjusted A1C (IDAA1C) as A1C (percent) + [4 x insulin dose (units per kilogram per 24 h)]. A calculated IDAA1C < or =9 corresponding to a predicted stimulated C-peptide >300 pmol/l was used to define partial remission. The IDAA1C < or =9 had a significantly higher agreement (P < 0.001) with residual beta-cell function than use of a definition of A1C < or =7.5%. Between 6 and 12 months after diagnosis, for IDAA1C < or =9 only 1 patient entered partial remission and 61 patients ended partial remission, for A1C < or =7.5% 15 patients entered partial remission and 53 ended, for a definition of insulin dose < or =0.5 units . kg(-1) . 24 h(-1) 5 patients entered partial remission and 66 ended, and for stimulated C-peptide (>300 pmol/l) 9 patients entered partial remission and 49 ended. IDAA1C at 6 months has good predictive power for stimulated C-peptide concentrations after both 6 and 12 months. CONCLUSIONS A new definition of partial remission is proposed, including both glycemic control and insulin dose. It reflects residual beta-cell function and has better stability compared with the conventional definitions.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hougaard, Philip
(författare)
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Swift, Peter
(författare)
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Hansen, Lars
(författare)
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Holl, Reinhard W.
(författare)
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Hoey, Hilary
(författare)
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Bjoerndalen, Hilde
(författare)
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de Beaufort, Carine
(författare)
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Chiarelli, Francesco
(författare)
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Danne, Thomas
(författare)
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Schoenle, Eugen J.
(författare)
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Åman, JanÖrebro universitet,Hälsoakademin(Swepub:oru)jnaa
(författare)
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Örebro universitetHälsoakademin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes Care: American Diabetes Association32:8, s. 1384-13900149-59921935-5548
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- Av författaren/redakt...
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Mortensen, Henri ...
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Hougaard, Philip
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Swift, Peter
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Hansen, Lars
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Holl, Reinhard W ...
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Hoey, Hilary
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visa fler...
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Bjoerndalen, Hil ...
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de Beaufort, Car ...
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Chiarelli, Franc ...
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Danne, Thomas
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Schoenle, Eugen ...
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Åman, Jan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Örebro universitet