Sökning: onr:"swepub:oai:DiVA.org:oru-13082" >
Maternal country of...
Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring
-
- Holmlund, U. (författare)
- Stockholms universitet,Wenner-Grens institut
-
- Amoudruz, P. (författare)
- Stockholms universitet,Wenner-Grens institut
-
- Johansson, M. A. (författare)
- Stockholms universitet,Wenner-Grens institut
-
visa fler...
-
- Haileselassie, Y. (författare)
- Stockholms universitet,Wenner-Grens institut
-
- Ongoiba, A. (författare)
- Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Univ Bamako, Bamako, Mali
-
- Kayentao, K. (författare)
- Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Univ Bamako, Bamako, Mali
-
- Traoré, B. (författare)
- Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Univ Bamako, Bamako, Mali
-
- Doumbo, S. (författare)
- Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Univ Bamako, Bamako, Mali
-
- Schollin, Jens (författare)
- Örebro universitet,Hälsoakademin
-
- Doumbo, O. (författare)
- Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Univ Bamako, Bamako, Mali
-
- Montgomery, Scott M. (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,Dept Med, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden; Dept Primary Care & Social Med, Charing Cross Hosp, Univ London Imperial Coll Sci Technol & Med, London, England
-
- Sverremark-Ekström, E. (författare)
- Stockholms universitet,Avdelningen för immunologi
-
visa färre...
-
(creator_code:org_t)
- 2010-10-05
- 2010
- Engelska.
-
Ingår i: Clinical and Experimental Immunology. - Oxford, Untited Kingdom : Wiley-Blackwell Publishing Inc.. - 0009-9104 .- 1365-2249. ; 162:3, s. 500-509
- Relaterad länk:
-
https://www.ncbi.nlm...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Breast milk contains pro- and anti-inflammatory cytokines and chemokines with potential to influence immunological maturation in the child. We have shown previously that country of birth is associated with the cytokine/chemokine profile of breast milk. In this study we have investigated how these differences in breast milk affect the cellular response of cord blood mononuclear cells (CBMCs) and intestinal epithelial cells (IECs, cell line HT-29) to microbial challenge. Ninety-five women were included: 30 from Mali in West Africa, 32 Swedish immigrants and 33 native Swedish women. CBMCs or IECs were stimulated in vitro with breast milk, alone or in combination with lipopolysaccharide (LPS) or peptidoglycan (PGN). Breast milk in general abrogated the LPS-induced down-regulation of surface CD14 and Toll-like receptor (TLR)-4 expression on CB monocytes, while inhibiting the PGN-induced TLR-2 up-regulation. However, breast milk from immigrant women together with LPS induced a lower CBMC release of interleukin (IL)-6 (P = 0 center dot 034) and CXCL-8/IL-8 (P = 0 center dot 037) compared with breast milk from Swedish women, while breast milk from Swedish women and Mali women tended to increase the response. The same pattern of CXCL-8/IL-8 release could be seen after stimulation of IECs (HT-29). The lower CBMC and IEC (HT-29) responses to microbial compounds by breast milk from immigrant women could be explained by the fact that breast milk from the immigrant group showed a divergent pro- and anti-inflammatory content for CXCL-8/IL-8, transforming growth factor-beta 1 and soluble CD14, compared to the other two groups of women. This may have implications for maturation of their children's immune responses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- Growth-factor-beta
- pattern-recognition receptor
- inflammatory-bowel-disease
- soluble cd14
- nonallergic mothers
- atopic disease
- iga production
- secretory iga
- ethnic-groups
- cytokines
- MEDICINE
- MEDICIN
- Internal medicine
- Invärtesmedicin
- Paediatric medicine
- Pediatrisk medicin
- Pediatrik
- Pediatrics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Holmlund, U.
-
Amoudruz, P.
-
Johansson, M. A.
-
Haileselassie, Y ...
-
Ongoiba, A.
-
Kayentao, K.
-
visa fler...
-
Traoré, B.
-
Doumbo, S.
-
Schollin, Jens
-
Doumbo, O.
-
Montgomery, Scot ...
-
Sverremark-Ekstr ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Immunologi
- Artiklar i publikationen
-
Clinical and Exp ...
- Av lärosätet
-
Örebro universitet
-
Stockholms universitet
-
Karolinska Institutet