Sökning: onr:"swepub:oai:DiVA.org:oru-17113" >
Insulin degludec in...
Insulin degludec in type 1 diabetes : a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine
-
Birkeland, Kare I. (författare)
-
Home, Philip D. (författare)
-
Wendisch, Ulrich (författare)
-
visa fler...
-
Ratner, Robert E. (författare)
-
Johansen, Thue (författare)
-
Endahl, Lars A. (författare)
-
Lyby, Karsten (författare)
-
- Jendle, Johan (författare)
- Örebro universitet,Hälsoakademin
-
Roberts, Anthony P. (författare)
-
DeVries, J. Hans (författare)
-
Meneghini, Luigi F. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2011-02-17
- 2011
- Engelska.
-
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 34:3, s. 661-665
- Relaterad länk:
-
https://care.diabete...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: Insulin degludec (IDeg) is a basal insulin that forms soluble multihexamers after subcutaneous injection, resulting in an ultra-long action profile. We assessed the efficacy and safety of IDeg formulations administered once daily in combination with mealtime insulin aspart in people with type 1 diabetes.RESEARCH DESIGN AND METHODS: In this 16-week, randomized, open-label trial, participants (mean: 45.8 years old, A1C 8.4%, fasting plasma glucose [FPG] 9.9 mmol/L, BMI 26.9 kg/m(2)) received subcutaneous injections of IDeg(A) (600 mu mol/L; n = 59), IDeg(B) (900 mu mol/L; n = 60), or insulin glargine (IGlar; n = 59), all given once daily in the evening. Insulin aspart was administered at mealtimes.RESULTS: At 16 weeks, mean A1C was comparable for IDeg(A) (7.8 +/- 0.8%), IDeg(B) (8.0 +/- 1.0%), and IGlar (7.6 +/- 0.8%), as was FPG (8.3 +/- 4.0, 8.3 +/- 2.8, and 8.9 +/- 3.5 mmol/L, respectively). Estimated mean rates of confirmed hypoglycemia were 28% lower for IDeg(A) compared with IGlar (rate ratio [RR]: 0.72 [95% CI 0.52-1.00]) and 10% lower for IDeg(B) compared with IGlar (RR: 0.90 [0.65-1.24]); rates of nocturnal hypoglycemia were 58% lower for IDeg(A) (RR: 0.42 [0.25-0.69]) and 29% lower for IDeg(B) (RR: 0.71 [0.44-1.16]). Mean total daily insulin dose was similar to baseline. The frequency and pattern of adverse events was similar between insulin treatments.CONCLUSIONS: In this clinical exploratory phase 2 trial in people with type 1 diabetes, IDeg is safe and well tolerated and provides comparable glycemic control to IGlar at similar doses, with reduced rates of hypoglycemia.
Nyckelord
- MEDICINE
- MEDICIN
- Medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Birkeland, Kare ...
-
Home, Philip D.
-
Wendisch, Ulrich
-
Ratner, Robert E ...
-
Johansen, Thue
-
Endahl, Lars A.
-
visa fler...
-
Lyby, Karsten
-
Jendle, Johan
-
Roberts, Anthony ...
-
DeVries, J. Hans
-
Meneghini, Luigi ...
-
visa färre...
- Artiklar i publikationen
-
Diabetes Care
- Av lärosätet
-
Örebro universitet