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The S-100B substudy...
The S-100B substudy of the GLUTAMICS-trial : glutamate infusion not associated with sustained elevation of plasma S-100B after coronary surgery
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- Vidlund, Mårten (författare)
- Örebro universitet,Hälsoakademin,Department of Cardiothoracic Surgery and Anesthesia, University Hospital Örebro, Sweden
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- Holm, Jonas (författare)
- Östergötlands Läns Landsting,Thorax-kärlkliniken
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- Håkanson, Erik (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Thorax-kärlkliniken,Thoraxkirurgi,Hälsouniversitetet
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- Friberg, Örjan (författare)
- Dept Cardiothorac Surg & Anesthesia, Univ Hosp Örebro, Örebro, Sweden,Department of Cardiothoracic Surgery and Anesthesia, University Hospital Örebro, Sweden
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- Sunnermalm, Lena (författare)
- Dept Cardiothorac Surg & Anesthesia, Univ Hosp Örebro, Örebro, Sweden,Department of Cardiothoracic Surgery and Anesthesia, University Hospital Örebro, Sweden
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- Vánky, Farkas (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Thorax-kärlkliniken,Thoraxkirurgi,Hälsouniversitetet
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- Svedjeholm, Rolf (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Thorax-kärlkliniken,Thoraxkirurgi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Clinical Nutrition. - : Elsevier BV. - 0261-5614 .- 1532-1983. ; 29:3, s. 358-364
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background & aimsConcerns have been raised about potential neurological injury related to exogenous glutamate. In cardiac surgery glutamate has been administered as a putative cardioprotective agent by cardioplegia or intravenous infusion. In the GLUTAMICS trial, in addition to surveillance of clinical neurological injuries, a prespecified subgroup was analyzed with regard to postoperative S-100B levels to detect potential subclinical neurological injury related to glutamate infusion.MethodsSixty-nine patients operated on for unstable coronary syndrome were randomized to intravenous infusion of glutamate (n=35) or saline (n=34) perioperatively. Plasma levels of S-100B were obtained on the third postoperative day.ResultsS-100B in the glutamate group and the control group were 0.079±0.034μg/L and 0.090±0.042μg/L respectively (p=0.245). There were no patients with stroke or mortality. Three patients in the control group and two in the glutamate group had postoperative confusion. These patients had significantly elevated S-100B compared with those without confusion (0.132±0.047vs 0.081±0.036μg/L; p=0.003). Overall, 21 patients had S-100B above reference level (≥0.10μg/L) and these patients had significantly more calcifications in the ascending aorta on epiaortic scanning.ConclusionsIntravenous glutamate infusion during surgery for unstable coronary artery disease did not initiate a sustained elevation of plasma S-100B. Thus, no evidence for subclinical neurological injury related to glutamate infusion was found. In contrast, postoperative elevation of plasma S-100B was linked to calcification of the ascending aorta and postoperative confusion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Glutamate
- Neurological injury
- Nutrition
- Coronary artery bypass surgery
- Myocardial protection
- Stroke
- Medicine
- Medicin
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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